UBE4B

UBE4B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KRE, 3L1X, 3L1Z
Dynodwyr
Cyfenwau	UBE4B, E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
Dynodwyr allanol	OMIM: 613565 HomoloGene: 107623 GeneCards: UBE4B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ATPase binding • GO:0050372 ubiquitin-protein transferase activity • enzyme binding • ATP binding • transferase activity • ubiquitin-ubiquitin ligase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • ubiquitin ligase complex • cnewyllyn cell • cytoplasm Prosesau biolegol • protein monoubiquitination • response to endoplasmic reticulum stress • ventricular trabecula myocardium morphogenesis • protein ubiquitination • neuron projection development • granzyme-mediated apoptotic signaling pathway • response to UV • proteasome-mediated ubiquitin-dependent protein catabolic process • protein autoubiquitination • protein polyubiquitination • ubiquitin-dependent ERAD pathway • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10277	n/a
Ensembl	ENSG00000130939	n/a
UniProt	O95155	n/a
RefSeq (mRNA)	NM_001105562 NM_006048	n/a
RefSeq (protein)	NP_001099032 NP_006039	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE4B yw UBE4B a elwir hefyd yn Ubiquitination factor E4B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE4B.

• E4
• UFD2
• HDNB1
• UBOX3
• UFD2A

Llyfryddiaeth

• "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2. ". Oncogene. 2003. PMID 12700669.
• "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. ". Oncogene. 2000. PMID 10980605.
• "Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma. ". Mol Carcinog. 2016. PMID 25557723.
• "UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors. ". Cancer. 2013. PMID 22990745.
• "The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death.". Biochem Biophys Res Commun. 2006. PMID 16870146.