UBE2N

UBE2N
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J7D, 2C2V, 3HCT, 3HCU, 3VON, 3W31, 4DHI, 4DHJ, 4DHZ, 4IP3, 4NR3, 4NRG, 4NRI, 4ONL, 4ONM, 4ONN, 4ORH, 4TKP, 5AIT, 5AIU, 4WHV
Dynodwyr
Cyfenwau	UBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
Dynodwyr allanol	OMIM: 603679 HomoloGene: 128406 GeneCards: UBE2N
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin binding • GO:0001948, GO:0016582 protein binding • ATP binding • ubiquitin protein ligase binding • RNA binding • GO:0050372 ubiquitin-protein transferase activity • ubiquitin conjugating enzyme activity Cydrannau o'r gell • cytoplasm • cytosol • UBC13-UEV1A complex • ubiquitin ligase complex • nucleoplasm • extracellular exosome • UBC13-MMS2 complex • cnewyllyn cell • fibrillar center • GO:0009327 protein-containing complex Prosesau biolegol • postreplication repair • protein K63-linked ubiquitination • regulation of DNA repair • DNA double-strand break processing • GO:1900404 positive regulation of DNA repair • stimulatory C-type lectin receptor signaling pathway • proteolysis • cellular response to DNA damage stimulus • Fc-epsilon receptor signaling pathway • global genome nucleotide-excision repair • GO:0033129 positive regulation of histone modification • positive regulation of ubiquitin-protein transferase activity • protein ubiquitination • regulation of histone ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • T cell receptor signaling pathway • double-strand break repair via nonhomologous end joining • nucleotide-binding oligomerization domain containing signaling pathway • histone ubiquitination • GO:0100026 DNA repair • double-strand break repair via homologous recombination • JNK cascade • positive regulation of NF-kappaB transcription factor activity • ubiquitin-dependent protein catabolic process • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7334	n/a
Ensembl	ENSG00000177889	n/a
UniProt	P61088	n/a
RefSeq (mRNA)	NM_003348	n/a
RefSeq (protein)	NP_003339	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2N yw UBE2N a elwir hefyd yn Ubiquitin conjugating enzyme E2 N (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2N.

• UBC13
• UbcH13
• HEL-S-71
• UbcH-ben
• UBCHBEN
• UBC13

Llyfryddiaeth

• "The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. ". Nature. 2012. PMID 22407319.
• "Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. ". J Biochem. 1996. PMID 8902611.
• "A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. ". Cell Death Dis. 2014. PMID 24556694.
• "Complex structure of OspI and Ubc13: the molecular basis of Ubc13 deamidation and convergence of bacterial and host E2 recognition. ". PLoS Pathog. 2013. PMID 23633953.
• "Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.". J Mol Biol. 2013. PMID 23542009.