UBE2I

UBE2I
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A3S, 1KPS, 1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2O25, 2PE6, 2PX9, 2XWU, 3A4S, 3UIN, 3UIO, 3UIP, 4Y1L, 4W5V, 2VRR, 5D2M, 5F6D, 5F6U, 5F6W, 5F6E, 5F6X, 5F6V, 5F6Y
Dynodwyr
Cyfenwau	UBE2I, C358B7.1, P18, UBC9, ubiquitin conjugating enzyme E2 I
Dynodwyr allanol	OMIM: 601661 HomoloGene: 5574 GeneCards: UBE2I
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • SUMO transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transcription factor binding • RING-like zinc finger domain binding • HLH domain binding • GO:0001948, GO:0016582 protein binding • enzyme binding • SUMO conjugating enzyme activity • ATP binding • ubiquitin protein ligase binding • transferase activity • RNA binding • small protein activating enzyme binding • GO:0050372 ubiquitin-protein transferase activity • protein C-terminus binding • bHLH transcription factor binding Cydrannau o'r gell • cytoplasm • PML body • nuclear body • nucleoplasm • transferase complex • synaptonemal complex • cnewyllyn cell • cytosol • sumoylated E2 ligase complex • fibrillar center • nuclear envelope • dendrite • synapse Prosesau biolegol • ubiquitin-dependent protein catabolic process • chromosome segregation • protein sumoylation • Cellraniad • global genome nucleotide-excision repair • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell cycle • positive regulation of SUMO transferase activity • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of signaling receptor activity • protein ubiquitination • positive regulation of intracellular steroid hormone receptor signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7329	n/a
Ensembl	ENSG00000103275	n/a
UniProt	P63279	n/a
RefSeq (mRNA)	NM_003345 NM_194259 NM_194260 NM_194261	n/a
RefSeq (protein)	NP_003336 NP_919235 NP_919236 NP_919237	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2I yw UBE2I a elwir hefyd yn Ubiquitin conjugating enzyme E2 I (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2I.

• P18
• UBC9
• C358B7.1

Llyfryddiaeth

• "RWD Domain as an E2 (Ubc9)-Interaction Module. ". J Biol Chem. 2015. PMID 25918163.
• "Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9. ". Proc Natl Acad Sci U S A. 2015. PMID 25805818.
• "Autophagy regulates UBC9 levels during viral-mediated tumorigenesis. ". PLoS Pathog. 2017. PMID 28253371.
• "Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. ". EMBO J. 2016. PMID 27174643.
• "Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems.". J Biol Chem. 2016. PMID 26697886.