UBE2D2

UBE2D2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UR6, 1W4U, 2CLW, 2ESK, 2ESO, 2ESP, 2ESQ, 3A33, 3JVZ, 3JW0, 3L1Y, 3TGD, 3ZNI, 4A49, 4A4B, 4A4C, 4AUQ, 4DDG, 4LDT, 4V3K, 4V3L, 4WZ3, 5D1L, 5D1K, 5D0M, 5D0K, 5D1M, 5EDV
Dynodwyr
Cyfenwau	UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
Dynodwyr allanol	OMIM: 602962 HomoloGene: 2506 GeneCards: UBE2D2
EC number	2.3.2.24
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • ATP binding • ubiquitin conjugating enzyme activity • ubiquitin protein ligase binding Cydrannau o'r gell • cytosol • ubiquitin ligase complex • nucleoplasm • extracellular exosome • GO:0009327 protein-containing complex Prosesau biolegol • ubiquitin-dependent protein catabolic process • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • protein K48-linked ubiquitination • regulation of transcription from RNA polymerase II promoter in response to hypoxia • T cell receptor signaling pathway • protein autoubiquitination • protein ubiquitination • MyD88-independent toll-like receptor signaling pathway • protein targeting to peroxisome • protein K11-linked ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7322	n/a
Ensembl	ENSG00000131508	n/a
UniProt	P62837	n/a
RefSeq (mRNA)	NM_003339 NM_181838	n/a
RefSeq (protein)	NP_003330 NP_862821	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2D2 yw UBE2D2 a elwir hefyd yn Ubiquitin conjugating enzyme E2 D2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2D2.

• UBC4
• PUBC1
• UBCH4
• UBC4/5
• UBCH5B
• E2(17)KB2

Llyfryddiaeth

• "HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas. ". J Hematol Oncol. 2012. PMID 22989009.
• "Protein substrate discrimination in the quiescin sulfhydryl oxidase (QSOX) family. ". Biochemistry. 2012. PMID 22582951.
• "Solution structure of the ubiquitin-conjugating enzyme UbcH5B. ". J Mol Biol. 2004. PMID 15522302.
• "Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. ". Sci Rep. 2016. PMID 26912277.
• "Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID 23027739.