UBC

UBC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1C3T, 1CMX, 1D3Z, 1F9J, 1FXT, 1G6J, 1GJZ, 1NBF, 1OGW, 1Q5W, 1S1Q, 1SIF, 1TBE, 1UBI, 1UBQ, 1UD7, 1XD3, 1XQQ, 1YX5, 1YX6, 1ZGU, 2AYO, 2BGF, 2DEN, 2FUH, 2G45, 2GBJ, 2GBK, 2GBM, 2GBN, 2GBR, 2GMI, 2HTH, 2IBI, 2J7Q, 2JF5, 2JRI, 2JY6, 2JZZ, 2K25, 2K6D, 2K8B, 2K8C, 2KDF, 2KJH, 2KLG, 2KN5, 2KX0, 2L3Z, 2LD9, 2LVO, 2LVP, 2LVQ, 2LZ6, 2MBO, 2MBQ, 2MCN, 2MI8, 2MJ5, 2MOR, 2MRE, 2MWS, 2N2K, 2NR2, 2O6V, 2OJR, 2PE9, 2PEA, 2RR9, 2RU6, 2W9N, 2WDT, 2XEW, 2Z59, 2ZCB, 2ZVN, 2ZVO, 3A33, 3ALB, 3AUL, 3B08, 3B0A, 3BY4, 3C0R, 3DVG, 3DVN, 3EEC, 3EFU, 3EHV, 3H7P, 3H7S, 3HM3, 3IFW, 3IHP, 3JSV, 3JVZ, 3JW0, 3K9O, 3K9P, 3KVF, 3KW5, 3LDZ, 3MHS, 3MTN, 3N30, 3N32, 3N3K, 3NS8, 3O65, 3OFI, 3OJ4, 3ONS, 3PRM, 3PT2, 3PTF, 3Q3F, 3RUL, 3TMP, 3U30, 3UGB, 3V6C, 3V6E, 3VFK, 3VUW, 3VUX, 3VUY, 3WXE, 3WXF, 3ZNI, 3ZNZ, 4AUQ, 4BOS, 4BOZ, 4BVU, 4DDG, 4DDI, 4DHJ, 4DHZ, 4FJV, 4HK2, 4HXD, 4I6L, 4I6N, 4IG7, 4IUM, 4JQW, 4K1R, 4K7S, 4K7U, 4K7W, 4KSK, 4KSL, 4LCD, 4LDT, 4MDK, 4MM3, 4MSM, 4MSQ, 4NQK, 4UN2, 4V3K, 4V3L, 5AIU, 4XOK, 5AF6, 5AF5, 5AF4, 4XOL, 5C7J, 5C7M, 5E6J, 4ZQS, 4AP4,%%s4AP4
Dynodwyr
Cyfenwau	UBC, HMG20, Ubiquitin C
Dynodwyr allanol	OMIM: 191340 HomoloGene: 128418 GeneCards: UBC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protease binding • GO:0001948, GO:0016582 protein binding • RNA binding • protein tag • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • endocytic vesicle membrane • cytosol • cnewyllyn cell • extracellular exosome • Cellbilen • nucleoplasm • endosome membrane • extracellular space • mitochondrial outer membrane • endoplasmic reticulum quality control compartment • fesigl • endoplasmic reticulum membrane • host cell Prosesau biolegol • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of epidermal growth factor receptor signaling pathway • interstrand cross-link repair • nucleotide-excision repair, DNA damage recognition • positive regulation of canonical Wnt signaling pathway • tumor necrosis factor-mediated signaling pathway • regulation of type I interferon production • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • endosomal transport • global genome nucleotide-excision repair • NIK/NF-kappaB signaling • G2/M transition of mitotic cell cycle • stress-activated MAPK cascade • transforming growth factor beta receptor signaling pathway • macroautophagy • negative regulation of canonical Wnt signaling pathway • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • regulation of tumor necrosis factor-mediated signaling pathway • stimulatory C-type lectin receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • JNK cascade • regulation of transcription from RNA polymerase II promoter in response to hypoxia • nucleotide-excision repair, DNA incision • I-kappaB kinase/NF-kappaB signaling • innate immune response • Notch signaling pathway • regulation of mRNA stability • protein polyubiquitination • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • virion assembly • positive regulation of NF-kappaB transcription factor activity • anaphase-promoting complex-dependent catabolic process • negative regulation of type I interferon production • nucleotide-binding oligomerization domain containing signaling pathway • GO:0046795 intracellular transport of virus • GO:0019067 viral life cycle • MyD88-dependent toll-like receptor signaling pathway • error-prone translesion synthesis • MAPK cascade • fibroblast growth factor receptor signaling pathway • cludo transmembrane rhwng ïonau • glycogen biosynthetic process • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • translesion synthesis • transcription-coupled nucleotide-excision repair • T cell receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • nucleotide-excision repair, DNA incision, 5'-to lesion • Wnt signaling pathway • nucleotide-excision repair, DNA duplex unwinding • regulation of signal transduction by p53 class mediator • ERBB2 signaling pathway • nucleotide-excision repair, preincision complex assembly • Wnt signaling pathway, planar cell polarity pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of epidermal growth factor receptor signaling pathway • protein folding • negative regulation of G2/M transition of mitotic cell cycle • protein ubiquitination • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • entry of bacterium into host cell • transmembrane transport • regulation of necroptotic process • membrane organization • endoplasmic reticulum mannose trimming • cellular iron ion homeostasis • regulation of hematopoietic stem cell differentiation • protein targeting to peroxisome • cytokine-mediated signaling pathway • modification-dependent protein catabolic process • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7316	n/a
Ensembl	ENSG00000150991	n/a
UniProt	P0CG48	n/a
RefSeq (mRNA)	NM_021009	n/a
RefSeq (protein)	NP_066289	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBC yw UBC a elwir hefyd yn Polyubiquitin-C ac Ubiquitin C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBC.

• HMG20

Llyfryddiaeth

• "The emerging complexity of ubiquitin architecture. ". J Biochem. 2017. PMID 28011818.
• "Regulation of primary cilia formation by the ubiquitin-proteasome system. ". Biochem Soc Trans. 2016. PMID 27911708.
• "Slow conformational exchange and overall rocking motion in ubiquitin protein crystals. ". Nat Commun. 2017. PMID 28747759.
• "Identification of primary and secondary UBA footprints on the surface of ubiquitin in cell-mimicking crowded solution. ". FEBS Lett. 2017. PMID 28267209.
• "Ubiquitin recognition by the proteasome.". J Biochem. 2017. PMID 28069863.