UBB

UBB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KHW, 2MBB, 2MRO, 2MSG, 4UEL, 4UF6, 4WLR, 4WUR, 4ZPZ, 5CAW, 3OJ3, 5DK8, 5CRA, 4ZFR, 5CVO, 3ZLZ, 4WHV, 4ZFT, 3ZNH, 5D0M, 2Y5B, 2KWV, 5D0K, 5DFL, 5CVM, 4WZP, 5EDV, 5CVN, 2KWU, 4XOF, 5BNB, 2N13, 4ZUX, 5IFR, 5IBK, 5KGF, 5JG6, 5K9P, 5E6J
Dynodwyr
Cyfenwau	UBB, HEL-S-50, Ubiquitin B
Dynodwyr allanol	OMIM: 191339 HomoloGene: 75104 GeneCards: UBB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein tag • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • endocytic vesicle membrane • cytosol • mitocondria • neuron projection • cnewyllyn cell • extracellular exosome • Cellbilen • nucleoplasm • neuronal cell body • endosome membrane • extracellular space • mitochondrial outer membrane • endoplasmic reticulum quality control compartment • fesigl • endoplasmic reticulum membrane • host cell Prosesau biolegol • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of epidermal growth factor receptor signaling pathway • interstrand cross-link repair • nucleotide-excision repair, DNA damage recognition • positive regulation of canonical Wnt signaling pathway • tumor necrosis factor-mediated signaling pathway • regulation of type I interferon production • positive regulation of protein monoubiquitination • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • endosomal transport • global genome nucleotide-excision repair • NIK/NF-kappaB signaling • G2/M transition of mitotic cell cycle • stress-activated MAPK cascade • transforming growth factor beta receptor signaling pathway • macroautophagy • negative regulation of canonical Wnt signaling pathway • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • regulation of tumor necrosis factor-mediated signaling pathway • stimulatory C-type lectin receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • JNK cascade • regulation of transcription from RNA polymerase II promoter in response to hypoxia • nucleotide-excision repair, DNA incision • I-kappaB kinase/NF-kappaB signaling • innate immune response • Notch signaling pathway • neuron projection morphogenesis • regulation of mRNA stability • protein polyubiquitination • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • virion assembly • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of NF-kappaB transcription factor activity • anaphase-promoting complex-dependent catabolic process • negative regulation of type I interferon production • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein ubiquitination • GO:0046795 intracellular transport of virus • regulation of proteasomal protein catabolic process • GO:0019067 viral life cycle • MyD88-dependent toll-like receptor signaling pathway • error-prone translesion synthesis • MAPK cascade • regulation of mitochondrial membrane potential • fibroblast growth factor receptor signaling pathway • cludo transmembrane rhwng ïonau • glycogen biosynthetic process • regulation of neuron death • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • translesion synthesis • transcription-coupled nucleotide-excision repair • mitochondrion transport along microtubule • T cell receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of signal transduction by p53 class mediator • positive regulation of epidermal growth factor receptor signaling pathway • Wnt signaling pathway • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision repair, DNA incision, 5'-to lesion • ERBB2 signaling pathway • Wnt signaling pathway, planar cell polarity pathway • nucleotide-excision repair, preincision complex assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • protein folding • negative regulation of G2/M transition of mitotic cell cycle • protein ubiquitination • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • entry of bacterium into host cell • transmembrane transport • regulation of necroptotic process • membrane organization • endoplasmic reticulum mannose trimming • cellular iron ion homeostasis • regulation of hematopoietic stem cell differentiation • protein targeting to peroxisome • male meiosis I • female meiosis I • male gonad development • female gonad development • cytokine-mediated signaling pathway • modification-dependent protein catabolic process • hypothalamus gonadotrophin-releasing hormone neuron development • adipose tissue development • fat pad development • interleukin-1-mediated signaling pathway • seminiferous tubule development • energy homeostasis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7314	n/a
Ensembl	ENSG00000170315	n/a
UniProt	P0CG47	n/a
RefSeq (mRNA)	NM_018955 NM_001281716 NM_001281717 NM_001281718 NM_001281719 NM_001281720	n/a
RefSeq (protein)	NP_001268645 NP_001268646 NP_001268647 NP_001268648 NP_001268649 NP_061828	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBB yw UBB a elwir hefyd yn Polyubiquitin-B ac Ubiquitin B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBB.

• HEL-S-50

Llyfryddiaeth

• "Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention. ". Sci Rep. 2013. PMID 24022007.
• "Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease. ". Neurochem Int. 2012. PMID 22797007.
• "Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1. ". FEBS Lett. 2016. PMID 27861798.
• "New crystal form of human ubiquitin in the presence of magnesium. ". Acta Crystallogr F Struct Biol Commun. 2016. PMID 26750481.
• "Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.". PLoS One. 2013. PMID 24367661.