UBASH3B

UBASH3B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CPW, 2E5K
Dynodwyr
Cyfenwau	UBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
Dynodwyr allanol	OMIM: 609201 HomoloGene: 13152 GeneCards: UBASH3B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein tyrosine phosphatase activity • GO:0001948, GO:0016582 protein binding • phosphoprotein phosphatase activity • hydrolase activity • identical protein binding • phosphoprotein binding • ubiquitin protein ligase binding • GO:0098519, GO:0098518 phosphatase activity Cydrannau o'r gell • cytoplasm • cnewyllyn cell Prosesau biolegol • regulation of release of sequestered calcium ion into cytosol • negative regulation of signal transduction • peptidyl-tyrosine dephosphorylation • negative regulation of platelet aggregation • regulation of osteoclast differentiation • negative regulation of protein kinase activity • negative regulation of osteoclast differentiation • negative regulation of bone resorption • platelet activation • collagen-activated tyrosine kinase receptor signaling pathway • collagen-activated signaling pathway • platelet aggregation • regulation of protein binding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84959	n/a
Ensembl	ENSG00000154127	n/a
UniProt	Q8TF42	n/a
RefSeq (mRNA)	NM_032873 NM_001363365	n/a
RefSeq (protein)	NP_116262 NP_001350294	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBASH3B yw UBASH3B a elwir hefyd yn Ubiquitin associated and SH3 domain containing B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBASH3B.

• p70
• STS1
• STS-1
• TULA2
• TULA-2

Llyfryddiaeth

• "Identification of STS-1 as a novel ShcA-binding protein. ". Biochem Biophys Res Commun. 2017. PMID 28690151.
• "UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. ". Leukemia. 2016. PMID 26449661.
• "Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice. ". Blood. 2015. PMID 26516227.
• "Placenta growth factor induces invasion and activates p70 during rapamycin treatment in trophoblast cells. ". Am J Reprod Immunol. 2015. PMID 25271148.
• "Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.". Proc Natl Acad Sci U S A. 2013. PMID 23784775.