UBA3

UBA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1R4M, 1R4N, 1TT5, 1Y8X, 1YOV, 2LQ7, 2NVU, 3DBH, 3DBL, 3DBR, 3FN1, 3GZN
Dynodwyr
Cyfenwau	UBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3
Dynodwyr allanol	OMIM: 603172 HomoloGene: 2951 GeneCards: UBA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • ligase activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • acid-amino acid ligase activity • NEDD8 activating enzyme activity • ubiquitin-like modifier activating enzyme activity • ATP binding • identical protein binding • NEDD8 transferase activity • nuclear receptor binding Cydrannau o'r gell • cnewyllyn cell • cytosol • cytoplasm • GO:0009327 protein-containing complex Prosesau biolegol • proteolysis • regulation of cell cycle • GO:0007067 Mitosis • endomitotic cell cycle • cell cycle • GO:0045996 negative regulation of transcription, DNA-templated • post-translational protein modification • protein neddylation • protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9039	n/a
Ensembl	ENSG00000144744	n/a
UniProt	Q8TBC4	n/a
RefSeq (mRNA)	NM_003968 NM_198195 NM_198197 NM_001363861	n/a
RefSeq (protein)	NP_003959 NP_937838 NP_001350790	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBA3 yw UBA3 a elwir hefyd yn Ubiquitin like modifier activating enzyme 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBA3.

• NAE2
• UBE1C
• hUBA3

Llyfryddiaeth

• "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. ". Mol Cell. 2003. PMID 14690597.
• "Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. ". Oncotarget. 2014. PMID 25229838.
• "Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. ". PLoS One. 2014. PMID 24691136.
• "Suppression of tumor angiogenesis by targeting the protein neddylation pathway. ". Cell Death Dis. 2014. PMID 24525735.
• "E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition.". Proteins. 2012. PMID 22821745.