UAP1

UAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JV1, 1JV3, 1JVD, 1JVG
Dynodwyr
Cyfenwau	UAP1, AGX, AGX1, AGX2, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1
Dynodwyr allanol	OMIM: 602862 HomoloGene: 2342 GeneCards: UAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • uridylyltransferase activity • nucleotidyltransferase activity • carbohydrate binding • identical protein binding • UDP-N-acetylglucosamine diphosphorylase activity Cydrannau o'r gell • Cellbilen • nucleoplasm • cytoplasm • cytosol Prosesau biolegol • UDP-N-acetylglucosamine metabolic process • metabolaeth • UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6675	n/a
Ensembl	ENSG00000117143	n/a
UniProt	Q16222	n/a
RefSeq (mRNA)	NM_003115 NM_001324113 NM_001324114 NM_001324115 NM_001324116 NM_001324117 NM_001388401 NM_001388402 NM_001399790 NM_001399791 NM_001399792 NM_001399793	n/a
RefSeq (protein)	NP_001311042 NP_001311043 NP_001311044 NP_001311045 NP_001311046 NP_003106	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UAP1 yw UAP1 a elwir hefyd yn UDP-N-acetylglucosamine pyrophosphorylase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UAP1.

• AGX
• AGX1
• AGX2
• SPAG2

Llyfryddiaeth

• "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa. ". Mol Reprod Dev. 1998. PMID 9621304.
• "Characterization of a human antigen with sera from infertile patients. ". Biol Reprod. 1994. PMID 8025165.
• "UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation. ". Oncogene. 2015. PMID 25241896.
• "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. ". EMBO J. 2001. PMID 11707391.
• "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc.". J Biol Chem. 1998. PMID 9765219.