U2AF2

U2AF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JMT, 1O0P, 1OPI, 1U2F, 2G4B, 2HZC, 2M0G, 2U2F, 2YH0, 2YH1, 3VAF, 3VAG, 3VAH, 3VAI, 3VAJ, 3VAK, 3VAL, 3VAM, 4FXW, 4TU7, 4TU8, 4TU9, 5EV1, 5EV3, 5EV4, 5EV2
Dynodwyr
Cyfenwau	U2AF2, U2AF65, U2 small nuclear RNA auxiliary factor 2
Dynodwyr allanol	OMIM: 191318 HomoloGene: 110853 GeneCards: U2AF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • pre-mRNA 3'-splice site binding • poly-pyrimidine tract binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • enzyme binding • C2H2 zinc finger domain binding • RNA binding Cydrannau o'r gell • nuclear speck • U2AF complex • Prp19 complex • spliceosomal complex • commitment complex • U2-type prespliceosome • cnewyllyn cell • nucleoplasm Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • positive regulation of protein targeting to mitochondrion • mRNA processing • mRNA export from nucleus • negative regulation of mRNA splicing, via spliceosome • regulation of autophagy of mitochondrion • positive regulation of RNA splicing • mRNA 3'-end processing • RNA splicing • RNA export from nucleus • negative regulation of protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11338	n/a
Ensembl	ENSG00000063244	n/a
UniProt	P26368	n/a
RefSeq (mRNA)	NM_001012478 NM_007279	n/a
RefSeq (protein)	NP_001012496 NP_009210	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn U2AF2 yw U2AF2 a elwir hefyd yn U2 small nuclear RNA auxiliary factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.42.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn U2AF2.

• U2AF65

Llyfryddiaeth

• "Splicing inhibition of U2AF65 leads to alternative exon skipping. ". Proc Natl Acad Sci U S A. 2015. PMID 26216990.
• "Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. ". Proc Natl Acad Sci U S A. 2014. PMID 25422459.
• "Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs. ". Genome Res. 2017. PMID 27927715.
• "An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. ". Nat Commun. 2016. PMID 26952537.
• "Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients.". J Cancer Res Clin Oncol. 2016. PMID 26687686.