U2AF1

U2AF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JMT
Dynodwyr
Cyfenwau	U2AF1, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1
Dynodwyr allanol	OMIM: 191317 HomoloGene: 134334 GeneCards: U2AF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • pre-mRNA 3'-splice site binding • RNA binding • RS domain binding Cydrannau o'r gell • Cajal body • nuclear speck • catalytic step 2 spliceosome • U2AF complex • nucleoplasm • spliceosomal complex • cnewyllyn cell Prosesau biolegol • termination of RNA polymerase II transcription • positive regulation of protein targeting to mitochondrion • mRNA processing • mRNA export from nucleus • regulation of autophagy of mitochondrion • RNA splicing • mRNA 3'-end processing • RNA export from nucleus • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7307	n/a
Ensembl	ENSG00000160201	n/a
UniProt	Q01081 P0DN76	n/a
RefSeq (mRNA)	NM_001025203 NM_001025204 NM_006758	n/a
RefSeq (protein)	NP_001307575 NP_001307577 NP_001307579 NP_001307580 NP_001020374 NP_001020375 NP_006749 NP_001020374 NP_001020375 NP_006749	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn U2AF1 yw U2AF1 a elwir hefyd yn U2 small nuclear RNA auxiliary factor 1 a Splicing factor U2AF 35 kDa subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn U2AF1.

• RN
• FP793
• U2AF35
• U2AFBP
• RNU2AF1

Llyfryddiaeth

• "Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival. ". PLoS Genet. 2016. PMID 27776121.
• "Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations. ". Blood Cancer J. 2016. PMID 27058230.
• "The high frequency of the U2AF1 S34Y mutation and its association with isolated trisomy 8 in myelodysplastic syndrome in Asians, but not in Caucasians. ". Leuk Res. 2017. PMID 28938223.
• "The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5' splice site that impacts splicing regulation in Q157R patients. ". RNA. 2017. PMID 28893951.
• "The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.". J Clin Invest. 2017. PMID 28436936.