TYROBP

TYROBP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2L34, 2L35, 4WO1, 4WOL
Dynodwyr
Cyfenwau	TYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP
Dynodwyr allanol	OMIM: 604142 HomoloGene: 7986 GeneCards: TYROBP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • GO:0001948, GO:0016582 protein binding • identical protein binding • metal ion binding Cydrannau o'r gell • integral component of membrane • cell surface • Cellbilen • integral component of plasma membrane • bilen • secretory granule membrane Prosesau biolegol • integrin-mediated signaling pathway • macrophage activation involved in immune response • cellular defense response • neutrophil activation involved in immune response • GO:0007243 intracellular signal transduction • innate immune response • regulation of osteoclast development • GO:0072468 signal transduction • regulation of immune response • neutrophil degranulation • osteoclast differentiation • myeloid leukocyte activation • positive regulation of natural killer cell activation • positive regulation of macrophage fusion • protein stabilization • positive regulation of microglial cell mediated cytotoxicity • positive regulation of protein localization to cell surface • positive regulation of osteoclast development • microglial cell activation involved in immune response • GO:1901313 positive regulation of gene expression • actin cytoskeleton organization • negative regulation of B cell proliferation • forebrain development • negative regulation of transforming growth factor beta1 production • positive regulation of superoxide anion generation • response to axon injury • apoptotic signaling pathway • positive regulation of hippocampal neuron apoptotic process • negative regulation of long-term synaptic potentiation • positive regulation of neuron death • positive regulation of receptor localization to synapse • apoptotic cell clearance • immune system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7305	n/a
Ensembl	ENSG00000011600	n/a
UniProt	O43914	n/a
RefSeq (mRNA)	NM_001173514 NM_001173515 NM_003332 NM_198125	n/a
RefSeq (protein)	NP_001166985 NP_001166986 NP_003323 NP_937758	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TYROBP yw TYROBP a elwir hefyd yn TYRO protein tyrosine kinase binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TYROBP.

• DAP12
• KARAP
• PLOSL

Llyfryddiaeth

• "DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells. ". J Leukoc Biol. 2013. PMID 23715743.
• "The association of polar residues in the DAP12 homodimer: TOXCAT and molecular dynamics simulation studies. ". Biophys J. 2013. PMID 23561520.
• "TYROBP genetic variants in early-onset Alzheimer's disease. ". Neurobiol Aging. 2016. PMID 27658901.
• "Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors. ". Cancer Immunol Res. 2015. PMID 25941351.
• "Breast cancer expression of DAP12 is associated with skeletal and liver metastases and poor survival.". Clin Breast Cancer. 2013. PMID 23810293.