TYMS

TYMS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YPV, 1JU6, 2RDA, 3EF9, 3ED7, 1HW3, 3EHI, 3GH0, 4JEF, 4O1X, 1HZW, 3EAW, 3OB7, 3EBU, 4KPW, 3EGY, 3EJL, 3N5G, 3N5E, 1HVY, 4GD7, 4G2O, 4H1I, 2ONB, 3H9K, 4GYH, 3HB8, 1I00, 3GG5, 4FGT, 2RD8, 3EDW, 4G6W, 1HW4, 3GH2, 4E28, 1JUJ, 4O1U, 4UP1, 5HS3,%%s1HW3, 1YPV, 4GD7, 2ONB
Dynodwyr
Cyfenwau	TYMS, HST422, TMS, TS, thymidylate synthetase
Dynodwyr allanol	OMIM: 188350 HomoloGene: 834 GeneCards: TYMS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • nucleotide binding • protein homodimerization activity • folic acid binding • thymidylate synthase activity • mRNA binding • translation repressor activity, mRNA regulatory element binding • sequence-specific mRNA binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • mitochondrial matrix • nucleolus • mitocondria • mitochondrial inner membrane • cnewyllyn cell Prosesau biolegol • response to cytokine • nucleotide biosynthetic process • DNA biosynthetic process • GO:1904578 response to organic cyclic compound • response to progesterone • tetrahydrofolate interconversion • GO:0010260 heneiddio • response to glucocorticoid • regulation of transcription involved in G1/S transition of mitotic cell cycle • dTTP biosynthetic process • tetrahydrofolate metabolic process • response to vitamin A • cartilage development • methylation • developmental growth • response to organophosphorus • Rhythm circadaidd • uracil metabolic process • dTMP biosynthetic process • intestinal epithelial cell maturation • dUMP metabolic process • response to folic acid • response to ethanol • response to toxic substance • pyrimidine nucleobase metabolic process • regulation of translation • liver regeneration • nucleobase-containing small molecule interconversion • negative regulation of translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7298	n/a
Ensembl	ENSG00000176890	n/a
UniProt	P04818 Q53Y97	n/a
RefSeq (mRNA)	NM_001071 NM_001354867 NM_001354868	n/a
RefSeq (protein)	NP_001062 NP_001341796 NP_001341797 NP_001062.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TYMS yw TYMS a elwir hefyd yn Thymidylate synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18p11.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TYMS.

• TS
• TMS
• HST422

Llyfryddiaeth

• "Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer. ". Anticancer Res. 2017. PMID 29187479.
• "The thymidylate synthase enhancer region (TSER) polymorphism increases the risk of thymic lymphoid hyperplasia in patients with Myasthenia Gravis. ". Gene. 2018. PMID 29162511.
• "Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. ". J Biol Chem. 2017. PMID 28634233.
• "Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India. ". Gene. 2017. PMID 28627444.
• "Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates.". Acta Crystallogr F Struct Biol Commun. 2017. PMID 28580921.