TYMP

TYMP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UOU, 2J0F, 2WK5, 2WK6
Dynodwyr
Cyfenwau	TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
Dynodwyr allanol	OMIM: 131222 HomoloGene: 1474 GeneCards: TYMP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glycosyltransferase activity • pyrimidine-nucleoside phosphorylase activity • growth factor activity • pentosyltransferase activity • 1,4-alpha-oligoglucan phosphorylase activity • thymidine phosphorylase activity • protein homodimerization activity Cydrannau o'r gell • cytosol Prosesau biolegol • cell differentiation • pyrimidine nucleoside salvage • pyrimidine nucleoside catabolic process • multicellular organism development • chemotaxis • angiogenesis • metabolaeth • pyrimidine nucleobase metabolic process • mitochondrial genome maintenance • pyrimidine nucleoside metabolic process • regulation of myelination • regulation of transmission of nerve impulse • regulation of gastric motility • regulation of signaling receptor activity • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1890	n/a
Ensembl	ENSG00000025708	n/a
UniProt	P19971	n/a
RefSeq (mRNA)	NM_001953 NM_001113755 NM_001113756 NM_001257988 NM_001257989	n/a
RefSeq (protein)	NP_001107227 NP_001107228 NP_001244917 NP_001244918 NP_001944	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TYMP yw TYMP a elwir hefyd yn Thymidine phosphorylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TYMP.

• TP
• ECGF
• ECGF1
• MNGIE
• MEDPS1
• MTDPS1
• PDECGF
• hPD-ECGF

Llyfryddiaeth

• "Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma. ". Lab Invest. 2017. PMID 28530649.
• "Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. ". Sci Transl Med. 2016. PMID 27559096.
• "Poor Prognosis Associated with High Levels of Thymidine Phosphorylase and Thrombocytosis in Patients with Renal Cell Carcinoma. ". Urol Int. 2017. PMID 27532673.
• "4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression. ". J Ovarian Res. 2014. PMID 25304388.
• "Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines.". Sci Rep. 2014. PMID 25027354.