TXK

TXK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DM0
Dynodwyr
Cyfenwau	TXK, BTKL, PSCTK5, PTK4, RLK, TKL, TXK tyrosine kinase
Dynodwyr allanol	OMIM: 600058 HomoloGene: 2497 GeneCards: TXK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • DNA binding • protein kinase activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • kinase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • signaling receptor binding • ATP binding • non-membrane spanning protein tyrosine kinase activity Cydrannau o'r gell • cytoplasm • bilen • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • adaptive immune response • phosphorylation • tissue regeneration • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0032617 cytokine production • positive regulation of interferon-gamma-mediated signaling pathway • positive regulation of interferon-gamma production • activation of phospholipase C activity • transcription, DNA-templated • protein phosphorylation • regulation of cell population proliferation • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • protein autophosphorylation • regulation of platelet activation • T cell receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7294	n/a
Ensembl	ENSG00000074966	n/a
UniProt	P42681	n/a
RefSeq (mRNA)	NM_003328	n/a
RefSeq (protein)	NP_003319	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TXK yw TXK a elwir hefyd yn TXK tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TXK.

• RLK
• TKL
• BTKL
• PTK4
• PSCTK5

Llyfryddiaeth

• "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. ". Biol Pharm Bull. 2002. PMID 12081135.
• "Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. ". J Exp Med. 1999. PMID 10523612.
• "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. ". Clin Med Res. 2006. PMID 16809408.
• "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. ". Hum Mol Genet. 1994. PMID 7951233.
• "Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.". J Biol Chem. 2015. PMID 25593320.