TWF1

TWF1
Dynodwyr
Cyfenwau	TWF1, A6, PTK9, twinfilin actin binding protein 1
Dynodwyr allanol	OMIM: 610932 HomoloGene: 48140 GeneCards: TWF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0032403 protein-containing complex binding • protein tyrosine kinase activity • ATP binding • actin monomer binding • phosphatidylinositol-4,5-bisphosphate binding • cadherin binding • actin binding • GO:0001948, GO:0016582 protein binding • actin filament binding Cydrannau o'r gell • intracellular anatomical structure • Cytosgerbwd • focal adhesion • filopodium • actin cytoskeleton • cell-cell junction • perinuclear region of cytoplasm • Myoffibril • ruffle membrane • cytoplasm • cytosol • Microffilament Prosesau biolegol • regulation of actin phosphorylation • barbed-end actin filament capping • sequestering of actin monomers • negative regulation of actin filament polymerization • positive regulation of cardiac muscle hypertrophy • regulation of lamellipodium assembly • positive regulation of neuron projection development • peptidyl-tyrosine phosphorylation • actin filament depolymerization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5756	n/a
Ensembl	ENSG00000151239	n/a
UniProt	Q12792	n/a
RefSeq (mRNA)	NM_001242397 NM_002822 NM_198974	n/a
RefSeq (protein)	NP_001229326 NP_002813	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TWF1 yw TWF1 a elwir hefyd yn Twinfilin actin binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TWF1.

• A6
• PTK9

Llyfryddiaeth

• "MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. ". Breast Cancer Res Treat. 2013. PMID 23224145.
• "A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. ". Hum Mutat. 2017. PMID 28493397.
• "The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers. ". Mol Biol Cell. 2002. PMID 12429826.
• "Prokaryotic expression cloning of a novel human tyrosine kinase. ". Mol Cell Biol. 1994. PMID 7507208.
• "MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.". Nat Commun. 2013. PMID 23340433.