TUBB4A

TUBB4A
Dynodwyr
Cyfenwau	TUBB4A, DYT4, TUBB4, TUBB5, beta-5, tubulin beta 4A class IVa
Dynodwyr allanol	OMIM: 602662 HomoloGene: 55952 GeneCards: TUBB4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GTP binding • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • calcium ion binding Cydrannau o'r gell • cytoplasm • cytosol • cell projection • myelin sheath • internode region of axon • cilium • neuronal cell body • microtubule • extracellular exosome • Cytosgerbwd • cnewyllyn cell • microtubule cytoskeleton • GO:0035085 axoneme Prosesau biolegol • G2/M transition of mitotic cell cycle • microtubule-based process • cytoskeleton organization • ciliary basal body-plasma membrane docking • negative regulation of microtubule polymerization • regulation of G2/M transition of mitotic cell cycle • microtubule cytoskeleton organization • GO:0007067 Mitosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10382	n/a
Ensembl	ENSG00000104833	n/a
UniProt	P04350	n/a
RefSeq (mRNA)	NM_006087 NM_001289123 NM_001289127 NM_001289129 NM_001289130 NM_001289131	n/a
RefSeq (protein)	NP_001276052 NP_001276056 NP_001276058 NP_001276059 NP_001276060 NP_006078	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TUBB4A yw TUBB4A a elwir hefyd yn Tubulin beta-4A chain a Tubulin beta 4A class IVa (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TUBB4A.

• DYT4
• TUBB4
• beta-5

Llyfryddiaeth

• "Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of βIVa-tubulin. ". Biochem Biophys Res Commun. 2015. PMID 26375501.
• "Large-scale TUBB4A mutational screening in isolated dystonia and controls. ". Parkinsonism Relat Disord. 2015. PMID 26318963.
• "Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth. ". Biochem Biophys Res Commun. 2018. PMID 29127012.
• TUBB4A-Related Leukodystrophy. 1993. PMID 27809427.
• "TUBB4A-related hypomyelinating leukodystrophy: New insights from a series of 12 patients.". Eur J Paediatr Neurol. 2016. PMID 26643067.