TTPA

TTPA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OIP, 1OIZ, 1R5L
Dynodwyr
Cyfenwau	TTPA, ATTP, AVED, TTP1, alphaTTP, tocopherol (alpha) transfer protein, alpha tocopherol transfer protein
Dynodwyr allanol	OMIM: 600415 HomoloGene: 37295 GeneCards: TTPA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • vitamin binding • vitamin E binding • phosphatidylinositol-3,4-bisphosphate binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate binding • lipid binding • lipid transfer activity Cydrannau o'r gell • cytoplasm • late endosome • cytosol Prosesau biolegol • intracellular pH reduction • response to nutrient • placenta development • lipid metabolism • embryonic placenta development • negative regulation of cell death • negative regulation of establishment of blood-brain barrier • response to pH • GO:0070904 vitamin transport • response to toxic substance • vitamin E metabolic process • intermembrane lipid transfer • GO:0007571 developmental process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7274	n/a
Ensembl	ENSG00000137561	n/a
UniProt	P49638	n/a
RefSeq (mRNA)	NM_000370	n/a
RefSeq (protein)	NP_000361	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TTPA yw TTPA a elwir hefyd yn Alpha tocopherol transfer protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TTPA.

• ATTP
• AVED
• TTP1
• alphaTTP

Llyfryddiaeth

• "Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWo. ". J Perinat Med. 2012. PMID 22752767.
• "The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP). ". J Mol Biol. 2011. PMID 21110980.
• "Alpha tocopherol transfer protein (αTTP) is expressed in endometrial carcinoma and is correlated with FIGO stage and 5-year survival. ". J Cancer Res Clin Oncol. 2017. PMID 28213729.
• "Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein. ". J Biol Chem. 2016. PMID 27307040.
• "Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms.". Free Radic Biol Med. 2012. PMID 23079030.