TSHR

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TSHR
Protein TSHR PDB 1XUM.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauTSHR, CHNG1, LGR3, hTSHR-I, thyroid stimulating hormone receptor, Thyrotropin receptor
Dynodwyr allanolOMIM: 603372 MGI: 98849 HomoloGene: 315 GeneCards: TSHR
Patrwm RNA pattern
PBB GE TSHR 210055 at fs.png

PBB GE TSHR 215442 s at fs.png

PBB GE TSHR 215443 at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000369
NM_001018036
NM_001142626

NM_001113404
NM_011648

RefSeq (protein)

NP_000360
NP_001018046
NP_001136098

NP_001106875
NP_035778

Lleoliad (UCSC)n/aChr : 91.38 – 91.55 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn TSHR yw TSHR a elwir hefyd yn Thyroid stimulating hormone receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q31.1.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TSHR.

  • LGR3
  • CHNG1
  • hTSHR-I

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. ". J Pediatr Endocrinol Metab. 2017. PMID 28195550.
  • "High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies. ". Clin Exp Immunol. 2017. PMID 28099999.
  • "Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?". Genet Mol Res. 2016. PMID 27525921.
  • "Association of polymorphisms of rs179247 and rs12101255 in thyroid stimulating hormone receptor intron 1 with an increased risk of Graves' disease: A meta-analysis. ". J Huazhong Univ Sci Technolog Med Sci. 2016. PMID 27465319.
  • "TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.". Endocr Rev. 2016. PMID 27454362.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. 1.0 1.1 1.2 GRCm38: Ensembl release 89: ENSMUSG00000020963 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. TSHR - Cronfa NCBI