TRIM63

TRIM63
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DDT, 4M3L, 2D8U
Dynodwyr
Cyfenwau	TRIM63, IRF, MURF1, MURF2, RNF28, SMRZ, tripartite motif containing 63
Dynodwyr allanol	OMIM: 606131 HomoloGene: 41878 GeneCards: TRIM63
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • GO:0001948, GO:0016582 protein binding • titin binding • signal transducer activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity Cydrannau o'r gell • cytoplasm • M band • contractile fiber • Z disc • microtubule • cnewyllyn cell • intracellular anatomical structure Prosesau biolegol • skeletal muscle atrophy • muscle contraction • response to glucocorticoid • response to interleukin-1 • protein ubiquitination • response to electrical stimulus involved in regulation of muscle adaptation • GO:0072468 signal transduction • negative regulation of cardiac muscle hypertrophy Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84676	n/a
Ensembl	ENSG00000158022	n/a
UniProt	Q969Q1	n/a
RefSeq (mRNA)	NM_032588	n/a
RefSeq (protein)	NP_115977	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRIM63 yw TRIM63 a elwir hefyd yn Tripartite motif containing 63 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRIM63.

• IRF
• SMRZ
• MURF1
• MURF2
• RNF28

Llyfryddiaeth

• "Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size. ". Int J Cardiol. 2013. PMID 22445192.
• "Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy. ". Cell Biochem Biophys. 2011. PMID 21448668.
• "Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy. ". Int J Mol Sci. 2014. PMID 24865491.
• "Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. ". Open Biol. 2014. PMID 24671946.
• "Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy.". Circ Res. 2012. PMID 22821932.