TRIM28

TRIM28
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FP0, 2RO1, 2YVR
Dynodwyr
Cyfenwau	TRIM28, KAP1, PPP1R157, RNF96, TF1B, TIF1B, tripartite motif containing 28, TIF1beta
Dynodwyr allanol	OMIM: 601742 HomoloGene: 21175 GeneCards: TRIM28
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase activity • Krueppel-associated box domain binding • chromo shadow domain binding • GO:0001106 transcription corepressor activity • promoter-specific chromatin binding • GO:0001105 transcription coactivator activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • chromatin binding • zinc ion binding • RNA binding • transferase activity • SUMO transferase activity Cydrannau o'r gell • intracellular anatomical structure • chromatin • RNA polymerase II transcription regulator complex • cnewyllyn cell • nucleoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • positive regulation of DNA methylation-dependent heterochromatin assembly • convergent extension involved in axis elongation • embryonic placenta morphogenesis • GO:1900404 positive regulation of DNA repair • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • negative regulation of DNA demethylation • protein phosphorylation • protein complex oligomerization • protein autophosphorylation • DNA methylation involved in embryo development • Ras protein signal transduction • transcription initiation from RNA polymerase II promoter • GO:0100026 DNA repair • embryo implantation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of genetic imprinting • protein sumoylation • epithelial to mesenchymal transition • protein ubiquitination • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of DNA binding • innate immune response • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0022415 viral process • positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10155	n/a
Ensembl	ENSG00000130726	n/a
UniProt	Q13263	n/a
RefSeq (mRNA)	NM_005762	n/a
RefSeq (protein)	NP_005753	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRIM28 yw TRIM28 a elwir hefyd yn Tripartite motif containing 28 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.43.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRIM28.

• KAP1
• TF1B
• RNF96
• TIF1B
• PPP1R157

Llyfryddiaeth

• "TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells. ". Cell Rep. 2017. PMID 28052240.
• "KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance. ". Int J Clin Oncol. 2016. PMID 27095111.
• "TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism. ". Biochem Biophys Res Commun. 2017. PMID 28864417.
• "Expression of tripartite motif-containing protein 28 in primary breast carcinoma predicts metastasis and is involved in the stemness, chemoresistance, and tumor growth. ". Tumour Biol. 2017. PMID 28381187.
• "Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells.". PLoS Pathog. 2017. PMID 28249048.