TRAF3

TRAF3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW
Dynodwyr
Cyfenwau	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
Dynodwyr allanol	OMIM: 601896 HomoloGene: 7981 GeneCards: TRAF3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • signal transducer activity • metal ion binding • GO:0001948, GO:0016582 protein binding • thioesterase binding • protein phosphatase binding • protein kinase binding • ubiquitin protein ligase binding • transferase activity • GO:0050372 ubiquitin-protein transferase activity • tumor necrosis factor receptor binding Cydrannau o'r gell • cytoplasm • cytosol • endosome • mitocondria • cytoplasmic side of plasma membrane • CD40 receptor complex • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • Toll signaling pathway • immune system process • TRIF-dependent toll-like receptor signaling pathway • protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • regulation of proteolysis • GO:0097285 apoptotic process • toll-like receptor signaling pathway • GO:0032657 regulation of cytokine production • GO:0072468 signal transduction • regulation of interferon-beta production • innate immune response • tumor necrosis factor-mediated signaling pathway • regulation of defense response to virus • protein deubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7187	n/a
Ensembl	ENSG00000131323	n/a
UniProt	Q13114	n/a
RefSeq (mRNA)	NM_001199427 NM_003300 NM_145725 NM_145726 NM_001385142 NM_001385143	n/a
RefSeq (protein)	NP_001186356 NP_003291 NP_663777 NP_663778	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRAF3 yw TRAF3 a elwir hefyd yn TNF receptor associated factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRAF3.

• CAP1
• LAP1
• CAP-1
• CRAF1
• IIAE5
• CD40bp
• RNF118

Llyfryddiaeth

• "Roles of TRAF3 in T cells: many surprises. ". Cell Cycle. 2015. PMID 25723057.
• "The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways. ". Cell Cycle. 2014. PMID 24739416.
• "Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production. ". J Biol Chem. 2016. PMID 27387501.
• "TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry. ". Biochim Biophys Acta. 2016. PMID 27208423.
• "TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke.". Stroke. 2016. PMID 27026631.