TPH1

TPH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MLW, 3HF6, 3HF8, 3HFB, 5J6D
Dynodwyr
Cyfenwau	TPH1, TPRH, TRPH, tryptophan hydroxylase 1
Dynodwyr allanol	OMIM: 191060 HomoloGene: 121565 GeneCards: TPH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • metal ion binding • monooxygenase activity • tryptophan 5-monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen • oxidoreductase activity Cydrannau o'r gell • cytoplasm • cytosol • neuron projection Prosesau biolegol • response to immobilization stress • mammary gland alveolus development • serotonin biosynthetic process • negative regulation of ossification • aromatic amino acid family metabolic process • bone remodeling • Rhythm circadaidd • positive regulation of fat cell differentiation • indolalkylamine biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7166	n/a
Ensembl	ENSG00000129167	n/a
UniProt	P17752	n/a
RefSeq (mRNA)	NM_004179	n/a
RefSeq (protein)	NP_004170	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPH1 yw TPH1 a elwir hefyd yn Tryptophan hydroxylase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPH1.

• TPRH
• TRPH

Llyfryddiaeth

• "Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition. ". Neuropsychology. 2016. PMID 26710093.
• "Association between the TPH1 A218C polymorphism and antidepressant response: evidence from an updated ethnicity, antidepressant-specific, and ethnicity-antidepressant interaction meta-analysis. ". Psychiatr Genet. 2015. PMID 25419635.
• "TPH1 A218 allele is associated with suicidal behavior in Turkish population. ". Leg Med (Tokyo). 2016. PMID 27497328.
• "The regulatory domain of human tryptophan hydroxylase 1 forms a stable dimer. ". Biochem Biophys Res Commun. 2016. PMID 27255998.
• "Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events.". Suicide Life Threat Behav. 2016. PMID 27037949.