TP53BP2

TP53BP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YCS, 2UWQ, 4A63, 4IRV
Dynodwyr
Cyfenwau	TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Dynodwyr allanol	OMIM: 602143 HomoloGene: 3959 GeneCards: TP53BP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • p53 binding • SH3 domain binding • NF-kappaB binding Cydrannau o'r gell • perinuclear region of cytoplasm • cnewyllyn cell • cytoplasm • mitocondria • nucleoplasm • cytosol • cell junction Prosesau biolegol • cell cycle • negative regulation of cell cycle • positive regulation of execution phase of apoptosis • GO:0072468 signal transduction • intrinsic apoptotic signaling pathway by p53 class mediator • GO:0097285 apoptotic process • positive regulation of neuron death • regulation of signal transduction by p53 class mediator • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7159	n/a
Ensembl	ENSG00000143514	n/a
UniProt	Q13625	n/a
RefSeq (mRNA)	NM_001031685 NM_005426	n/a
RefSeq (protein)	NP_001026855 NP_005417	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP53BP2 yw TP53BP2 a elwir hefyd yn Tumor protein p53 binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q41.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP53BP2.

• BBP
• 53BP2
• ASPP2
• P53BP2
• PPP1R13A

Llyfryddiaeth

• "Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2. ". Proc Natl Acad Sci U S A. 2014. PMID 24474782.
• "Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function. ". PLoS One. 2013. PMID 24312625.
• "miR-548d-3p/TP53BP2 axis regulates the proliferation and apoptosis of breast cancer cells. ". Cancer Med. 2016. PMID 26663100.
• "Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation. ". Mol Cancer. 2015. PMID 26438046.
• "An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA.". Biochemistry. 2015. PMID 25963096.