TOP2B

TOP2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3QX3, 4G0U, 4G0V, 4G0W, 4J3N
Dynodwyr
Cyfenwau	TOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU
Dynodwyr allanol	OMIM: 126431 HomoloGene: 134711 GeneCards: TOP2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity • nucleotide binding • DNA binding • histone deacetylase binding • chromatin binding • isomerase activity • metal ion binding • DNA topoisomerase activity • protein C-terminus binding • protein heterodimerization activity • enzyme binding • ATP binding • protein kinase C binding • ribonucleoprotein complex binding Cydrannau o'r gell • cytosol • nucleoplasm • GO:0035328 heterochromatin • nucleolus • cnewyllyn cell • cytoplasm • ribonucleoprotein complex • viral integration complex Prosesau biolegol • resolution of meiotic recombination intermediates • axonogenesis • DNA metabolic process • neuron migration • forebrain development • mitotic DNA integrity checkpoint signaling • sister chromatid segregation • DNA topological change • positive regulation of single stranded viral RNA replication via double stranded DNA intermediate Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7155	n/a
Ensembl	ENSG00000077097	n/a
UniProt	Q02880	n/a
RefSeq (mRNA)	NM_001068 NM_001330700	n/a
RefSeq (protein)	NP_001059 NP_001317629	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOP2B yw TOP2B a elwir hefyd yn DNA topoisomerase II beta a DNA topoisomerase 2-beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TOP2B.

• TOPIIB
• top2beta

Llyfryddiaeth

• "Etoposide quinone is a covalent poison of human topoisomerase IIβ. ". Biochemistry. 2014. PMID 24766193.
• "Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site. ". Proteomics. 2011. PMID 21280220.
• "Topoisomerase IIβ and its role in different biological contexts. ". Arch Biochem Biophys. 2017. PMID 28669856.
• "DNA topoisomerase IIβ as a molecular switch in neural differentiation of mesenchymal stem cells. ". Ann Hematol. 2015. PMID 25217229.
• "Specificity protein 1 regulates topoisomerase IIβ expression in SH-SY5Y cells during neuronal differentiation.". J Neurosci Res. 2014. PMID 24801450.