TOLLIP

TOLLIP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WGL, 2N31
Dynodwyr
Cyfenwau	TOLLIP, IL-1RAcPIP, toll interacting protein
Dynodwyr allanol	OMIM: 606277 HomoloGene: 10375 GeneCards: TOLLIP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signal transducer activity • Toll-like receptor binding • SUMO binding • kinase binding • GO:0001948, GO:0016582 protein binding • interleukin-1, type I receptor binding • ubiquitin protein ligase binding • ubiquitin conjugating enzyme binding • ubiquitin binding Cydrannau o'r gell • interleukin-18 receptor complex • cytosol • nuclear body • perinuclear region of cytoplasm • interleukin-1 receptor complex • extracellular exosome • extracellular region • cytoplasm • azurophil granule lumen • specific granule lumen Prosesau biolegol • GO:0007243 intracellular signal transduction • epithelial cell differentiation • phosphorylation • immune system process • leukocyte activation • cell-cell signaling • positive regulation of protein sumoylation • autophagy • protein localization to endosome • innate immune response • inflammatory response • GO:0072468 signal transduction • ubiquitin-dependent protein catabolic process • neutrophil degranulation • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54472	n/a
Ensembl	ENSG00000078902	n/a
UniProt	Q9H0E2 Q6FIE9	n/a
RefSeq (mRNA)	NM_019009 NM_001318512 NM_001318514 NM_001318515 NM_001318516	n/a
RefSeq (protein)	NP_001305441 NP_001305443 NP_001305444 NP_001305445 NP_061882 NP_061882.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOLLIP yw TOLLIP a elwir hefyd yn Toll interacting protein, isoform CRA_b a Toll interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TOLLIP.

• IL-1RAcPIP

Llyfryddiaeth

• "Toll-interacting protein inhibits HIV-1 infection and regulates viral latency. ". Biochem Biophys Res Commun. 2016. PMID 27181351.
• "Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. ". Am J Transplant. 2016. PMID 26663441.
• "A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis. ". Am J Respir Crit Care Med. 2017. PMID 28463648.
• "Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. ". Clin Exp Allergy. 2016. PMID 27513438.
• "Pharmacogenetics and interstitial lung disease.". Curr Opin Pulm Med. 2016. PMID 27253772.