TOB1

TOB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D5R, 2Z15, 5CI8, 5CI9
Dynodwyr
Cyfenwau	TOB1, APRO6, PIG49, TOB, TROB, TROB1, transducer of ERBB2, 1, APRO5
Dynodwyr allanol	OMIM: 605523 HomoloGene: 31334 GeneCards: TOB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • receptor tyrosine kinase binding • SMAD binding • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity Cydrannau o'r gell • CCR4-NOT complex • cytoplasm • cnewyllyn cell Prosesau biolegol • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • negative regulation of osteoblast differentiation • negative regulation of nuclear-transcribed mRNA poly(A) tail shortening • negative regulation of nucleic acid-templated transcription • negative regulation of BMP signaling pathway • negative regulation of translation • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • BMP signaling pathway • negative regulation of cell population proliferation • positive regulation of signal transduction • regulation of SMAD protein signal transduction • regulation of gene expression Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10140	n/a
Ensembl	ENSG00000141232	n/a
UniProt	P50616	n/a
RefSeq (mRNA)	NM_005749 NM_001243877 NM_001243885	n/a
RefSeq (protein)	NP_001230806 NP_001230814 NP_005740	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOB1 yw TOB1 a elwir hefyd yn Transducer of ERBB2, 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TOB1.

• TOB
• TROB
• APRO5
• APRO6
• PIG49
• TROB1

Llyfryddiaeth

• "Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathway. ". Oncol Rep. 2013. PMID 23589165.
• "Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1). ". Acta Pharmacol Sin. 2012. PMID 22158108.
• "Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation. ". Oncogene. 2016. PMID 26165839.
• "Clinicopathological significance of cytoplasmic transducer of ErbB2. 1 expression in gastric cancer. ". Mol Med Rep. 2015. PMID 25760308.
• "Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway.". Oncol Rep. 2013. PMID 23756562.