TNNC1

TNNC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AP4, 1IH0, 1J1D, 1J1E, 1LXF, 1MXL, 1OZS, 1SPY, 1WRK, 1WRL, 2JT0, 2JT3, 2JT8, 2JTZ, 2JXL, 2KDH, 2KFX, 2KGB, 2KRD, 2L1R, 2L98, 2MKP, 2MLE, 2MLF, 2MZP, 3RV5, 3SD6, 3SWB, 4GJE, 4GJF, 4GJG, 2N79, 4Y99
Dynodwyr
Cyfenwau	TNNC1, CMD1Z, CMH13, TN-C, TNC, TNNC, Troponin C type 1, troponin C1, slow skeletal and cardiac type
Dynodwyr allanol	OMIM: 191040 HomoloGene: 55728 GeneCards: TNNC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • protein homodimerization activity • troponin T binding • metal ion binding • calcium-dependent protein binding • GO:0001948, GO:0016582 protein binding • troponin I binding • actin filament binding Cydrannau o'r gell • cytosol • troponin complex • contractile fiber • cardiac Troponin complex Prosesau biolegol • regulation of muscle contraction • transition between fast and slow fiber • diaphragm contraction • response to metal ion • ventricular cardiac muscle tissue morphogenesis • muscle filament sliding • regulation of muscle filament sliding speed • regulation of ATP-dependent activity • skeletal muscle contraction • cardiac muscle contraction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7134	n/a
Ensembl	ENSG00000114854	n/a
UniProt	P63316	n/a
RefSeq (mRNA)	NM_003280	n/a
RefSeq (protein)	NP_003271	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNNC1 yw TNNC1 a elwir hefyd yn Troponin C1, slow skeletal and cardiac type (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNNC1.

• TNC
• TN-C
• TNNC
• CMD1Z
• CMH13

Llyfryddiaeth

• "The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q. ". J Mol Cell Cardiol. 2015. PMID 26341255.
• "In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. ". Circ Cardiovasc Genet. 2015. PMID 26304555.
• "Use of the HEART Pathway with high sensitivity cardiac troponins: A secondary analysis. ". Clin Biochem. 2017. PMID 28087371.
• "Evidence for troponin C (TNNC1) as a gene for autosomal recessive restrictive cardiomyopathy with fatal outcome in infancy. ". Am J Med Genet A. 2016. PMID 27604170.
• "Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C.". Arch Biochem Biophys. 2016. PMID 26976709.