TNK2

TNK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CF4, 1U46, 1U4D, 1U54, 3EQP, 3EQR, 4EWH, 4HZR, 4HZS, 4ID7
Dynodwyr
Cyfenwau	TNK2, ACK, ACK-1, ACK1, p21cdc42Hs, tyrosine kinase non receptor 2
Dynodwyr allanol	OMIM: 606994 HomoloGene: 4224 GeneCards: TNK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • epidermal growth factor receptor binding • GTPase inhibitor activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • WW domain binding • protein tyrosine kinase activity • ATP binding • ubiquitin protein ligase binding • non-membrane spanning protein tyrosine kinase activity • protein serine/threonine/tyrosine kinase activity Cydrannau o'r gell • endosome • bilen • extrinsic component of cytoplasmic side of plasma membrane • adherens junction • Cellbilen • cell junction • Grb2-EGFR complex • clathrin-coated pit • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • clathrin-coated vesicle • cytoplasm • perinuclear region of cytoplasm • cytoophidium Prosesau biolegol • cell differentiation • endocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • small GTPase mediated signal transduction • protein phosphorylation • cell surface receptor signaling pathway • regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • regulation of clathrin-dependent endocytosis • innate immune response • cell migration • GO:0034259 negative regulation of GTPase activity • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10188	n/a
Ensembl	ENSG00000061938	n/a
UniProt	Q07912	n/a
RefSeq (mRNA)	NM_001010938 NM_001308046 NM_005781 NM_001382271 NM_001382272 NM_001382273 NM_001382274 NM_001382275	n/a
RefSeq (protein)	NP_001010938 NP_001294975 NP_005772	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNK2 yw TNK2 a elwir hefyd yn Activated CDC42 kinase 1 a Tyrosine kinase non receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q29.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNK2.

• ACK
• ACK1
• ACK-1
• p21cdc42Hs

Llyfryddiaeth

• "Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation. ". Oncotarget. 2017. PMID 26498357.
• "ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling. ". Int J Oncol. 2015. PMID 25738261.
• "Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms. ". Med Sci Monit. 2016. PMID 27926694.
• "Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. ". Cancer Res. 2016. PMID 26677978.
• "Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.". Oncotarget. 2015. PMID 26536663.