TNFSF18

TNFSF18
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Q1M, 2R30, 2R32, 3B93, 3B94
Dynodwyr
Cyfenwau	TNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
Dynodwyr allanol	OMIM: 603898 HomoloGene: 3732 GeneCards: TNFSF18
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • signaling receptor binding • GO:0001948, GO:0016582 protein binding • tumor necrosis factor receptor superfamily binding • identical protein binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • extracellular space • cell surface Prosesau biolegol • adaptive immune response • positive regulation of leukocyte migration • immune system process • cell-cell signaling • negative regulation of apoptotic process • GO:0072468 signal transduction • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • T cell proliferation involved in immune response • tumor necrosis factor-mediated signaling pathway • regulation of T cell proliferation • positive regulation of cell adhesion • positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8995	n/a
Ensembl	ENSG00000120337	n/a
UniProt	Q9UNG2	n/a
RefSeq (mRNA)	NM_005092	n/a
RefSeq (protein)	NP_005083	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFSF18 yw TNFSF18 a elwir hefyd yn TNF superfamily member 18 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFSF18.

• TL6
• AITRL
• GITRL
• TNLG2A
• hGITRL

Llyfryddiaeth

• "Correlation of circulating glucocorticoid-induced TNFR-related protein ligand levels with disease activity in patients with systemic lupus erythematosus. ". Clin Dev Immunol. 2012. PMID 23251213.
• "GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity. ". J Immunol. 2012. PMID 22649191.
• "GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis. ". Clin Rheumatol. 2016. PMID 27098050.
• "GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis. ". Oncotarget. 2016. PMID 26657118.
• "Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.". Int J Mol Sci. 2014. PMID 25429429.