TNFRSF1A

TNFRSF1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EXT, 1FT4, 1ICH, 1NCF, 1TNR
Dynodwyr
Cyfenwau	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A
Dynodwyr allanol	OMIM: 191190 HomoloGene: 828 GeneCards: TNFRSF1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • tumor necrosis factor binding • identical protein binding Cydrannau o'r gell • integral component of membrane • Golgi apparatus • bilen • Golgi membrane • receptor complex • Cellbilen • integral component of plasma membrane • extracellular region • cell surface • mitocondria • membrane raft • extracellular space • tumor necrosis factor receptor superfamily complex Prosesau biolegol • regulation of apoptotic process • prostaglandin metabolic process • defense response • positive regulation of ceramide biosynthetic process • positive regulation of inflammatory response • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • death-inducing signaling complex assembly • regulation of cell population proliferation • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0022415 viral process • I-kappaB kinase/NF-kappaB signaling • negative regulation of inflammatory response • regulation of establishment of endothelial barrier • extrinsic apoptotic signaling pathway via death domain receptors • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • GO:0097285 apoptotic process • inflammatory response • cell surface receptor signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • protein localization to plasma membrane • cytokine-mediated signaling pathway • aortic valve development • pulmonary valve development • negative regulation of extracellular matrix constituent secretion • negative regulation of cardiac muscle hypertrophy • positive regulation of apoptotic process involved in morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7132	n/a
Ensembl	ENSG00000067182	n/a
UniProt	P19438	n/a
RefSeq (mRNA)	NM_001065 NM_001346091 NM_001346092	n/a
RefSeq (protein)	NP_001056 NP_001333020 NP_001333021	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFRSF1A yw TNFRSF1A a elwir hefyd yn Tumor necrosis factor receptor superfamily member 1A a TNF receptor superfamily member 1a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFRSF1A.

• FPF
• p55
• p60
• TBP1
• TNF-R
• TNFAR
• TNFR1
• p55-R
• CD120a
• TNFR55
• TNFR60
• TNF-R-I
• TNF-R55

Llyfryddiaeth

• "Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey. ". Arthritis Rheumatol. 2016. PMID 27332769.
• "TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren's syndrome patients. ". Genet Mol Res. 2016. PMID 27323176.
• "Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. ". BMC Pediatr. 2017. PMID 28427379.
• "TNFR1 -383 A˃C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study. ". Genet Mol Res. 2017. PMID 28363009.
• "Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation.". Cell Microbiol. 2017. PMID 27684048.