TNFRSF14

TNFRSF14
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JMA, 2AW2, 4FHQ, 4RSU
Dynodwyr
Cyfenwau	TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, tumor necrosis factor receptor superfamily member 14, TNF receptor superfamily member 14
Dynodwyr allanol	OMIM: 602746 HomoloGene: 2833 GeneCards: TNFRSF14
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • virus receptor activity • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • ubiquitin protein ligase binding • GO:0019974 cytokine binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • external side of plasma membrane Prosesau biolegol • regulation of apoptotic process • T cell costimulation • tumor necrosis factor-mediated signaling pathway • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • apoptotic signaling pathway • viral entry into host cell • inflammatory response • GO:0022415 viral process • negative regulation of alpha-beta T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • GO:0051636 defense response to Gram-negative bacterium • GO:0051637 defense response to Gram-positive bacterium • positive regulation of T cell migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8764	n/a
Ensembl	ENSG00000273936 ENSG00000157873	n/a
UniProt	Q92956	n/a
RefSeq (mRNA)	NM_001297605 NM_003820	n/a
RefSeq (protein)	NP_001284534 NP_003811	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFRSF14 yw TNFRSF14 a elwir hefyd yn TNF receptor superfamily member 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFRSF14.

• TR2
• ATAR
• HVEA
• HVEM
• CD270
• LIGHTR

Llyfryddiaeth

• "Recurrent mutations in genes involved in nuclear factor-κB signalling in nodal marginal zone lymphoma-diagnostic and therapeutic implications. ". Histopathology. 2017. PMID 27297871.
• "Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene. ". Blood. 2016. PMID 27257180.
• "High expression of herpesvirus entry mediator (HVEM) in ovarian serous adenocarcinoma tissue. ". J BUON. 2017. PMID 28365939.
• "The paradoxical changes of membrane and soluble herpes virus entry mediator in hepatocellular carcinoma patients. ". J Gastroenterol Hepatol. 2017. PMID 27987232.
• "Knockdown of HVEM, a Lymphocyte Regulator Gene, in Ovarian Cancer Cells Increases Sensitivity to Activated T Cells.". Oncol Res. 2016. PMID 27458100.