TLR4

TLR4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA
Dynodwyr
Cyfenwau	TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
Dynodwyr allanol	OMIM: 603030 HomoloGene: 41317 GeneCards: TLR4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• lipopolysaccharide immune receptor activity; • lipopolysaccharide binding; • GO:0001948, GO:0016582 protein binding; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • bilen; • perinuclear region of cytoplasm; • cell surface; • integral component of membrane; • Cellbilen; • endosome membrane; • intrinsic component of plasma membrane; • integral component of plasma membrane; • lipopolysaccharide receptor complex; • external side of plasma membrane;
Prosesau biolegol	• positive regulation of MHC class II biosynthetic process; • positive regulation of JNK cascade; • TRIF-dependent toll-like receptor signaling pathway; • cellular response to mechanical stimulus; • positive regulation of interleukin-8 production; • positive regulation of ERK1 and ERK2 cascade; • T-helper 1 type immune response; • positive regulation of platelet activation; • positive regulation of interleukin-1 production; • positive regulation of stress-activated MAPK cascade; • positive regulation of NLRP3 inflammasome complex assembly; • positive regulation of interleukin-12 production; • positive regulation of interferon-alpha production; • I-kappaB phosphorylation; • positive regulation of nitric-oxide synthase biosynthetic process; • positive regulation of B cell proliferation; • defense response to bacterium; • positive regulation of interleukin-6 production; • activation of innate immune response; • positive regulation of tumor necrosis factor production; • negative regulation of tumor necrosis factor production; • innate immune response; • negative regulation of interleukin-17 production; • I-kappaB kinase/NF-kappaB signaling; • positive regulation of interferon-beta production; • positive regulation of inflammatory response; • toll-like receptor 4 signaling pathway; • positive regulation of macrophage cytokine production; • positive regulation of interleukin-10 production; • immune system process; • astrocyte development; • intestinal epithelial structure maintenance; • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; • response to lipopolysaccharide; • cellular response to lipoteichoic acid; • positive regulation of NF-kappaB transcription factor activity; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • negative regulation of interleukin-23 production; • regulation of inflammatory response; • positive regulation of chemokine production; • lipopolysaccharide-mediated signaling pathway; • detection of fungus; • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; • negative regulation of interferon-gamma production; • response to bacterium; • negative regulation of osteoclast differentiation; • B cell proliferation involved in immune response; • positive regulation of nitric oxide biosynthetic process; • negative regulation of interleukin-6 production; • positive regulation of interferon-gamma production; • nitric oxide production involved in inflammatory response; • MyD88-dependent toll-like receptor signaling pathway; • regulation of dendritic cell cytokine production; • GO:1901313 positive regulation of gene expression; • negative regulation of ERK1 and ERK2 cascade; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • macrophage activation; • detection of lipopolysaccharide; • cellular response to lipopolysaccharide; • positive regulation of lymphocyte proliferation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • MyD88-independent toll-like receptor signaling pathway; • GO:0072468 signal transduction; • inflammatory response; • GO:0051636 defense response to Gram-negative bacterium; • toll-like receptor signaling pathway; • GO:0060554, GO:0060555 necroptosis; • apoptotic signaling pathway; • negative regulation of MyD88-independent toll-like receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7099
	n/a
	ENSG00000136869
	n/a
	O00206
	n/a
	NM_138557; NM_003266; NM_138554; NM_138556
	n/a
	NP_003257; NP_612564; NP_612567
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR4 yw TLR4 a elwir hefyd yn Toll like receptor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR4.

TOLL
CD284
TLR-4
ARMD10

Llyfryddiaeth

"Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. ". PLoS One. 2017. PMID 29136006.
"Testing an association between TLR4 and CXCR1 gene polymorphisms with susceptibility to urinary tract infection in type 2 diabetes in north Indian population. ". Gene. 2018. PMID 29066305.
"TLR4-Mediated Inflammation Promotes KSHV-Induced Cellular Transformation and Tumorigenesis by Activating the STAT3 Pathway. ". Cancer Res. 2017. PMID 29051178.
"Down-regulation of Toll-like Receptor TLR4 Is Associated with HPV DNA Integration in Penile Carcinoma. ". Anticancer Res. 2017. PMID 28982864.
"TLR4 as a negative regulator of keratinocyte proliferation.". PLoS One. 2017. PMID 28982115.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TLR4 - Cronfa NCBI

[1]

[2]