TLR4

TLR4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA
Dynodwyr
Cyfenwau	TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
Dynodwyr allanol	OMIM: 603030 HomoloGene: 41317 GeneCards: TLR4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lipopolysaccharide immune receptor activity • lipopolysaccharide binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity Cydrannau o'r gell • cytoplasm • bilen • perinuclear region of cytoplasm • cell surface • integral component of membrane • Cellbilen • endosome membrane • intrinsic component of plasma membrane • integral component of plasma membrane • lipopolysaccharide receptor complex • external side of plasma membrane Prosesau biolegol • positive regulation of MHC class II biosynthetic process • positive regulation of JNK cascade • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of ERK1 and ERK2 cascade • T-helper 1 type immune response • positive regulation of platelet activation • positive regulation of interleukin-1 production • positive regulation of stress-activated MAPK cascade • positive regulation of NLRP3 inflammasome complex assembly • positive regulation of interleukin-12 production • positive regulation of interferon-alpha production • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of B cell proliferation • defense response to bacterium • positive regulation of interleukin-6 production • activation of innate immune response • positive regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • innate immune response • negative regulation of interleukin-17 production • I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-beta production • positive regulation of inflammatory response • toll-like receptor 4 signaling pathway • positive regulation of macrophage cytokine production • positive regulation of interleukin-10 production • immune system process • astrocyte development • intestinal epithelial structure maintenance • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • negative regulation of interleukin-23 production • regulation of inflammatory response • positive regulation of chemokine production • lipopolysaccharide-mediated signaling pathway • detection of fungus • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of interferon-gamma production • response to bacterium • negative regulation of osteoclast differentiation • B cell proliferation involved in immune response • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • positive regulation of interferon-gamma production • nitric oxide production involved in inflammatory response • MyD88-dependent toll-like receptor signaling pathway • regulation of dendritic cell cytokine production • GO:1901313 positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • macrophage activation • detection of lipopolysaccharide • cellular response to lipopolysaccharide • positive regulation of lymphocyte proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • MyD88-independent toll-like receptor signaling pathway • GO:0072468 signal transduction • inflammatory response • GO:0051636 defense response to Gram-negative bacterium • toll-like receptor signaling pathway • GO:0060554, GO:0060555 necroptosis • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7099	n/a
Ensembl	ENSG00000136869	n/a
UniProt	O00206	n/a
RefSeq (mRNA)	NM_138557 NM_003266 NM_138554 NM_138556	n/a
RefSeq (protein)	NP_003257 NP_612564 NP_612567	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR4 yw TLR4 a elwir hefyd yn Toll like receptor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR4.

• TOLL
• CD284
• TLR-4
• ARMD10

Llyfryddiaeth

• "Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. ". PLoS One. 2017. PMID 29136006.
• "Testing an association between TLR4 and CXCR1 gene polymorphisms with susceptibility to urinary tract infection in type 2 diabetes in north Indian population. ". Gene. 2018. PMID 29066305.
• "TLR4-Mediated Inflammation Promotes KSHV-Induced Cellular Transformation and Tumorigenesis by Activating the STAT3 Pathway. ". Cancer Res. 2017. PMID 29051178.
• "Down-regulation of Toll-like Receptor TLR4 Is Associated with HPV DNA Integration in Penile Carcinoma. ". Anticancer Res. 2017. PMID 28982864.
• "TLR4 as a negative regulator of keratinocyte proliferation.". PLoS One. 2017. PMID 28982115.