TLR3

TLR3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Dynodwyr
Cyfenwau	TLR3, CD283, IIAE2, toll like receptor 3, IMD83
Dynodwyr allanol	OMIM: 603029 HomoloGene: 20696 GeneCards: TLR3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • identical protein binding; • RNA binding; • double-stranded RNA binding; • transmembrane signaling receptor activity; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • endosome; • endoplasmic reticulum membrane; • bilen; • Golgi membrane; • integral component of plasma membrane; • intracellular anatomical structure; • cell surface; • lysosomal membrane; • early endosome; • Reticwlwm endoplasmig; • endolysosome membrane; • endosome membrane; • extracellular space; • GO:0005578 extracellular matrix;
Prosesau biolegol	• positive regulation of interferon-beta production; • response to dsRNA; • defense response; • positive regulation of toll-like receptor signaling pathway; • positive regulation of protein phosphorylation; • male gonad development; • positive regulation of inflammatory response; • positive regulation of interleukin-12 production; • positive regulation of type III interferon production; • cellular response to interferon-beta; • response to exogenous dsRNA; • negative regulation of osteoclast differentiation; • GO:0032737 positive regulation of cytokine production; • immune system process; • response to virus; • activation of NF-kappaB-inducing kinase activity; • I-kappaB phosphorylation; • positive regulation of JNK cascade; • hyperosmotic response; • cellular response to dsRNA; • regulation of dendritic cell cytokine production; • microglial cell activation; • toll-like receptor signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • cellular response to mechanical stimulus; • microglial cell activation involved in immune response; • GO:1901313 positive regulation of gene expression; • defense response to bacterium; • positive regulation of NF-kappaB transcription factor activity; • defense response to virus; • necroptotic signaling pathway; • positive regulation of interleukin-8 production; • cellular response to exogenous dsRNA; • positive regulation of interleukin-6 production; • positive regulation of tumor necrosis factor production; • cellular response to interferon-gamma; • positive regulation of chemokine production; • positive regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • detection of virus; • inflammatory response; • innate immune response; • I-kappaB kinase/NF-kappaB signaling; • toll-like receptor 3 signaling pathway; • positive regulation of type I interferon production; • MyD88-independent toll-like receptor signaling pathway; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0060554, GO:0060555 necroptosis; • apoptotic signaling pathway; • negative regulation of MyD88-independent toll-like receptor signaling pathway; • extrinsic apoptotic signaling pathway; • positive regulation of angiogenesis; • positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologau
	7098
	n/a
	ENSG00000164342
	n/a
	O15455
	n/a
	NM_003265
	n/a
	NP_003256
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR3 yw TLR3 a elwir hefyd yn Toll like receptor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q35.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR3.

CD283
IIAE2

Llyfryddiaeth

"TLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis. ". J Infect Dis. 2017. PMID 28368532.
"Association of Toll-like receptor 3 gene polymorphism with the severity of enterovirus 71 infection in Chinese children. ". Arch Virol. 2017. PMID 28190199.
"Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection. ". J Immunol Res. 2017. PMID 28127569.
"[Association of TLR3-1377C/T gene polymorphisms and expression with susceptibility to enterovirus 71 encephalitis in children]. ". Zhongguo Dang Dai Er Ke Za Zhi. 2017. PMID 28100320.
"Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children.". PLoS One. 2017. PMID 28046022.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TLR3 - Cronfa NCBI

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[2]