TLR3

TLR3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Dynodwyr
Cyfenwau	TLR3, CD283, IIAE2, toll like receptor 3, IMD83
Dynodwyr allanol	OMIM: 603029 HomoloGene: 20696 GeneCards: TLR3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • RNA binding • double-stranded RNA binding • transmembrane signaling receptor activity • signaling receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • endosome • endoplasmic reticulum membrane • bilen • Golgi membrane • integral component of plasma membrane • intracellular anatomical structure • cell surface • lysosomal membrane • early endosome • Reticwlwm endoplasmig • endolysosome membrane • endosome membrane • extracellular space • GO:0005578 extracellular matrix Prosesau biolegol • positive regulation of interferon-beta production • response to dsRNA • defense response • positive regulation of toll-like receptor signaling pathway • positive regulation of protein phosphorylation • male gonad development • positive regulation of inflammatory response • positive regulation of interleukin-12 production • positive regulation of type III interferon production • cellular response to interferon-beta • response to exogenous dsRNA • negative regulation of osteoclast differentiation • GO:0032737 positive regulation of cytokine production • immune system process • response to virus • activation of NF-kappaB-inducing kinase activity • I-kappaB phosphorylation • positive regulation of JNK cascade • hyperosmotic response • cellular response to dsRNA • regulation of dendritic cell cytokine production • microglial cell activation • toll-like receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • microglial cell activation involved in immune response • GO:1901313 positive regulation of gene expression • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • defense response to virus • necroptotic signaling pathway • positive regulation of interleukin-8 production • cellular response to exogenous dsRNA • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • cellular response to interferon-gamma • positive regulation of chemokine production • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • detection of virus • inflammatory response • innate immune response • I-kappaB kinase/NF-kappaB signaling • toll-like receptor 3 signaling pathway • positive regulation of type I interferon production • MyD88-independent toll-like receptor signaling pathway • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0060554, GO:0060555 necroptosis • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway • extrinsic apoptotic signaling pathway • positive regulation of angiogenesis • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7098	n/a
Ensembl	ENSG00000164342	n/a
UniProt	O15455	n/a
RefSeq (mRNA)	NM_003265	n/a
RefSeq (protein)	NP_003256	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR3 yw TLR3 a elwir hefyd yn Toll like receptor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q35.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR3.

• CD283
• IIAE2

Llyfryddiaeth

• "TLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis. ". J Infect Dis. 2017. PMID 28368532.
• "Association of Toll-like receptor 3 gene polymorphism with the severity of enterovirus 71 infection in Chinese children. ". Arch Virol. 2017. PMID 28190199.
• "Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection. ". J Immunol Res. 2017. PMID 28127569.
• "[Association of TLR3-1377C/T gene polymorphisms and expression with susceptibility to enterovirus 71 encephalitis in children]. ". Zhongguo Dang Dai Er Ke Za Zhi. 2017. PMID 28100320.
• "Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children.". PLoS One. 2017. PMID 28046022.