TLR2

TLR2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Dynodwyr
Cyfenwau	TLR2, CD282, TIL4, toll like receptor 2
Dynodwyr allanol	OMIM: 603028 HomoloGene: 20695 GeneCards: TLR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0008329 pattern recognition receptor activity • lipopolysaccharide binding • Toll-like receptor binding • triacyl lipopeptide binding • GO:0001948, GO:0016582 protein binding • peptidoglycan binding • protein heterodimerization activity • lipopolysaccharide immune receptor activity • transmembrane signaling receptor activity • lipopeptide binding Cydrannau o'r gell • cytoplasm • integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • bilen • intrinsic component of plasma membrane • Cellbilen • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • membrane raft • GO:0016023 cytoplasmic vesicle • cell projection • cell surface • cell body Prosesau biolegol • interleukin-10 production • positive regulation of interferon-beta production • GO:0051637 defense response to Gram-positive bacterium • positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of inflammatory response • cellular response to bacterial lipopeptide • positive regulation of interleukin-12 production • immune system process • detection of diacyl bacterial lipopeptide • cellular response to diacyl bacterial lipopeptide • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • positive regulation of Wnt signaling pathway • GO:1901313 positive regulation of gene expression • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of chemokine production • innate immune response • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • response to molecule of bacterial origin • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • response to lipopolysaccharide • response to progesterone • toll-like receptor signaling pathway • response to insulin • central nervous system myelin formation • nitric oxide metabolic process • response to fatty acid • leukotriene metabolic process • toll-like receptor 2 signaling pathway • positive regulation of oligodendrocyte differentiation • response to bacterial lipoprotein • negative regulation of cell population proliferation • response to toxic substance • response to hypoxia • positive regulation of interleukin-10 production • lipopolysaccharide-mediated signaling pathway • microglial cell activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7097	n/a
Ensembl	ENSG00000137462	n/a
UniProt	O60603	n/a
RefSeq (mRNA)	NM_003264 NM_001318787 NM_001318789 NM_001318790 NM_001318791 NM_001318793 NM_001318795 NM_001318796	n/a
RefSeq (protein)	NP_001305716 NP_001305718 NP_001305719 NP_001305720 NP_001305722 NP_001305724 NP_001305725 NP_003255	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR2 yw TLR2 a elwir hefyd yn Toll like receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR2.

• TIL4
• CD282

Llyfryddiaeth

• "Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. ". Infect Immun. 2018. PMID 29084899.
• "Toll-like receptor 2 and its roles in immune responses against Legionella pneumophila. ". Life Sci. 2017. PMID 28887059.
• "Toll-like receptor 2 and type 2 diabetes. ". Cell Mol Biol Lett. 2016. PMID 28536605.
• "Association of single-nucleotide polymorphisms in toll-like receptor 2 gene with asthma susceptibility: A meta-analysis. ". Medicine (Baltimore). 2017. PMID 28514297.
• "Surface Expression and Genetic Variants of Toll-like Receptor 2 in Pulmonary Tuberculosis Patients.". Egypt J Immunol. 2016. PMID 28502147.