TLR1

TLR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Z7X, 1FYV
Dynodwyr
Cyfenwau	TLR1, CD281, TIL, TIL. LPRS5, rsc786, toll like receptor 1
Dynodwyr allanol	OMIM: 601194 HomoloGene: 20694 GeneCards: TLR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • Toll-like receptor 2 binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • lipopeptide binding • transmembrane signaling receptor activity • signaling receptor activity • identical protein binding Cydrannau o'r gell • integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • bilen • Cellbilen • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • membrane raft • GO:0016023 cytoplasmic vesicle Prosesau biolegol • defense response • toll-like receptor TLR1:TLR2 signaling pathway • immune system process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • toll-like receptor 1 signaling pathway • macrophage activation • inflammatory response • GO:0072468 signal transduction • innate immune response • defense response to bacterium • cell activation • toll-like receptor signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of toll-like receptor 2 signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7096	n/a
Ensembl	ENSG00000174125	n/a
UniProt	Q15399	n/a
RefSeq (mRNA)	NM_003263	n/a
RefSeq (protein)	NP_003254	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLR1 yw TLR1 a elwir hefyd yn Toll like receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p14.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLR1.

• TIL
• CD281
• rsc786
• TIL.*LPRS5

Llyfryddiaeth

• "Toll-like Receptor 1 Polymorphisms Increased the Risk of Pulmonary Tuberculosis in an Iranian Population Sample. ". Biomed Environ Sci. 2016. PMID 27998389.
• "TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis. ". PLoS One. 2016. PMID 27214039.
• "Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab. ". Mol Cancer Ther. 2016. PMID 27196764.
• "A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria. ". Malar J. 2016. PMID 26738805.
• "A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.". J Immunol. 2016. PMID 26729809.