TLE3

TLE3
Dynodwyr
Cyfenwau	TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
Dynodwyr allanol	OMIM: 600190 HomoloGene: 21059 GeneCards: TLE3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • beta-catenin-TCF complex • transcription regulator complex Prosesau biolegol • animal organ morphogenesis • GO:0009373 regulation of transcription, DNA-templated • Wnt signaling pathway • transcription, DNA-templated • GO:0072468 signal transduction • beta-catenin-TCF complex assembly • negative regulation of canonical Wnt signaling pathway • negative regulation of cold-induced thermogenesis • negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7090	n/a
Ensembl	ENSG00000140332	n/a
UniProt	Q04726 Q6PRX3	n/a
RefSeq (mRNA)	NM_001105192 NM_001282979 NM_001282980 NM_001282981 NM_001282982 NM_005078 NM_020908	n/a
RefSeq (protein)	NP_001098662 NP_001269908 NP_001269909 NP_001269910 NP_001269911 NP_005069 NP_065959 NP_001269908.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLE3 yw TLE3 a elwir hefyd yn Transducin-like enhancer protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLE3.

• ESG
• ESG3
• GRG3
• HsT18976

Llyfryddiaeth

• "Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. ". Oncogene. 2004. PMID 15221013.
• "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. ". Genomics. 1996. PMID 8808280.
• "TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma. ". Cancer Epidemiol Biomarkers Prev. 2012. PMID 22194527.
• "Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness. ". J Cutan Pathol. 2011. PMID 22050093.
• "Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors.". Biochem Biophys Res Commun. 2007. PMID 18273443.