TLE1

TLE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GXR, 2CE8, 2CE9, 4OM2, 4OM3
Dynodwyr
Cyfenwau	TLE1, ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor, TLE-1
Dynodwyr allanol	OMIM: 600189 HomoloGene: 21058 GeneCards: TLE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • transcription factor binding • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • cytosol • cnewyllyn cell • nucleoplasm • beta-catenin-TCF complex • transcription regulator complex • cytoplasm • nucleolus Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • negative regulation of Wnt signaling pathway • Wnt signaling pathway • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • multicellular organism development • GO:1901313 positive regulation of gene expression • animal organ morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of anoikis • GO:0072468 signal transduction • GO:1901227 negative regulation of transcription by RNA polymerase II • beta-catenin-TCF complex assembly • negative regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7088	n/a
Ensembl	ENSG00000196781	n/a
UniProt	Q04724	n/a
RefSeq (mRNA)	NM_001303103 NM_001303104 NM_005077	n/a
RefSeq (protein)	NP_001290032 NP_001290033 NP_005068	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLE1 yw TLE1 a elwir hefyd yn Transducin-like enhancer protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLE1.

• ESG
• ESG1
• GRG1

Llyfryddiaeth

• "Immunohistochemical validation of TLE1, a novel marker, for synovial sarcomas. ". Indian J Med Res. 2012. PMID 23287123.
• "Specificity of TLE1 expression in unclassified high-grade sarcomas for the diagnosis of synovial sarcoma. ". Appl Immunohistochem Mol Morphol. 2013. PMID 23197007.
• "Ras-Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function. ". Oncogene. 2017. PMID 28192406.
• "Transducer-like enhancer of split 1 (TLE1) expression as a diagnostic immunohistochemical marker for synovial sarcoma and its association with morphological features. ". Malays J Pathol. 2016. PMID 27568668.
• "Reappraisal of TLE-1 immunohistochemical staining and molecular detection of SS18-SSX fusion transcripts for synovial sarcoma.". Pathol Int. 2013. PMID 24422953.