TK1

TK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1W4R, 1XBT, 2ORV, 2WVJ
Dynodwyr
Cyfenwau	TK1, TK2, Thymidine kinase 1
Dynodwyr allanol	OMIM: 188300 HomoloGene: 37749 GeneCards: TK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • nucleoside kinase activity • zinc ion binding • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • thymidine kinase • thymidine kinase activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • DNA biosynthetic process • phosphorylation • pyrimidine nucleoside salvage • nucleobase-containing compound metabolic process • protein homotetramerization • deoxyribonucleoside monophosphate biosynthetic process • DNA metabolic process • nucleotide biosynthetic process • thymidine metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7083	n/a
Ensembl	ENSG00000167900	n/a
UniProt	P04183	n/a
RefSeq (mRNA)	NM_003258 NM_001346663 NM_001363848	n/a
RefSeq (protein)	NP_001333592 NP_003249 NP_001350777	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TK1 yw TK1 a elwir hefyd yn Thymidine kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TK1.

• TK2

Llyfryddiaeth

• "Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1. ". Urol Oncol. 2015. PMID 26231311.
• "Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation. ". Anticancer Res. 2015. PMID 25964590.
• "A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease. ". Tumour Biol. 2016. PMID 27079872.
• "Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver. ". Anticancer Res. 2016. PMID 27069161.
• "Serum TK1 is a more reliable marker than CEA and AFP for cancer screening in a study of 56,286 people.". Cancer Biomark. 2016. PMID 27002755.