TJP2

TJP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OSG, 3E17
Dynodwyr
Cyfenwau	TJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2, FHCA1
Dynodwyr allanol	OMIM: 607709 HomoloGene: 3541 GeneCards: TJP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • protein domain specific binding • guanylate kinase activity • GO:0001948, GO:0016582 protein binding • cadherin binding Cydrannau o'r gell • bilen • bicellular tight junction • adherens junction • Cellbilen • cell junction • cnewyllyn cell • cytosol • nucleoplasm Prosesau biolegol • establishment of endothelial intestinal barrier • hippo signaling • regulation of membrane permeability • intestinal absorption • GMP metabolic process • GDP metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9414	n/a
Ensembl	ENSG00000119139	n/a
UniProt	Q9UDY2	n/a
RefSeq (mRNA)	NM_001170414 NM_001170415 NM_001170416 NM_001170630 NM_004817 NM_201629 NM_001369870 NM_001369871 NM_001369872 NM_001369873 NM_001369874 NM_001369875	n/a
RefSeq (protein)	NP_001163885 NP_001163886 NP_001163887 NP_004808 NP_963923	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TJP2 yw TJP2 a elwir hefyd yn Tight junction protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TJP2.

• ZO2
• X104
• PFIC4
• DFNA51
• DUP9q21.11
• C9DUPq21.11

Llyfryddiaeth

• "Mutations in TJP2 cause progressive cholestatic liver disease. ". Nat Genet. 2014. PMID 24614073.
• "Alu-related transcript of TJP2 gene as a marker for colorectal cancer. ". Gene. 2013. PMID 23612256.
• "Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. ". Exp Ther Med. 2017. PMID 29042928.
• "ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation. ". Ann N Y Acad Sci. 2017. PMID 28415133.
• "Hepatocellular carcinoma associated with tight-junction protein 2 deficiency.". Hepatology. 2015. PMID 25921221.