TIMP2

TIMP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BR9, 1GXD, 2TMP, 4ILW
Dynodwyr
Cyfenwau	TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2
Dynodwyr allanol	OMIM: 188825 HomoloGene: 2444 GeneCards: TIMP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • GO:0048551 enzyme inhibitor activity • metal ion binding • integrin binding • GO:0001948, GO:0016582 protein binding • protease binding • metalloendopeptidase inhibitor activity • zinc ion binding Cydrannau o'r gell • growth cone • extracellular region • cell surface • neuronal cell body • neuron projection • extracellular exosome • GO:0005578 extracellular matrix • extracellular space • specific granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of proteolysis • response to cytokine • negative regulation of peptidase activity • positive regulation of adenylate cyclase activity • GO:0010260 heneiddio • extracellular matrix disassembly • negative regulation of Ras protein signal transduction • central nervous system development • positive regulation of neuron differentiation • response to hormone • negative regulation of membrane protein ectodomain proteolysis • positive regulation of MAPK cascade • negative regulation of cell population proliferation • negative regulation of mitotic cell cycle • regulation of Rap protein signal transduction • negative regulation of endopeptidase activity • neutrophil degranulation • negative regulation of metallopeptidase activity • response to organic substance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7077	n/a
Ensembl	ENSG00000035862	n/a
UniProt	P16035	n/a
RefSeq (mRNA)	NM_003255	n/a
RefSeq (protein)	NP_003246	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TIMP2 yw TIMP2 a elwir hefyd yn TIMP metallopeptidase inhibitor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TIMP2.

• DDC8
• CSC-21K

Llyfryddiaeth

• "Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. ". Oncotarget. 2015. PMID 26556867.
• "TIMP-2 G-418C polymorphism and cancer risk: A meta-analysis. ". J Cancer Res Ther. 2015. PMID 26148591.
• "Reduced Scleral TIMP-2 Expression Is Associated With Myopia Development: TIMP-2 Supplementation Stabilizes Scleral Biomarkers of Myopia and Limits Myopia Development. ". Invest Ophthalmol Vis Sci. 2017. PMID 28384717.
• "May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?". Pathol Oncol Res. 2017. PMID 27853937.
• "Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.". J Clin Hypertens (Greenwich). 2016. PMID 27412873.