THPO

THPO
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V7M, 1V7N
Dynodwyr
Cyfenwau	THPO, MGDF, MKCSF, ML, MPLLG, THCYT1, TPO, thrombopoietin
Dynodwyr allanol	OMIM: 600044 HomoloGene: 398 GeneCards: THPO
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • growth factor activity • hormone activity • signaling receptor binding Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • multicellular organism development • positive regulation of hematopoietic stem cell proliferation • cell population proliferation • regulation of signaling receptor activity • positive regulation of protein phosphorylation • thrombopoietin-mediated signaling pathway • positive regulation of megakaryocyte differentiation • positive regulation of protein kinase B signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of cell population proliferation • myeloid cell differentiation • megakaryocyte development • positive regulation of MAPK cascade • receptor signaling pathway via STAT Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7066	n/a
Ensembl	ENSG00000090534	n/a
UniProt	P40225	n/a
RefSeq (mRNA)	NM_000460 NM_001177597 NM_001177598 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 NM_199228 NM_199356	n/a
RefSeq (protein)	NP_000451 NP_001171068 NP_001171069 NP_001276926 NP_001276927 NP_001276932 NP_001276951 NP_001276955 NP_001276956 NP_001276957	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn THPO yw THPO, a elwir hefyd yn Thrombopoietin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q27.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THPO.

• ML
• TPO
• MGDF
• MKCSF
• MPLLG
• THCYT1

Llyfryddiaeth

• "A novel role for thrombopoietin in regulating osteoclast development in humans and mice. ". J Cell Physiol. 2015. PMID 25656774.
• "Relationships of mean platelet volume and plasma thrombopoietin with glycocalicin levels in thrombocytopenic patients. ". Acta Haematol. 2015. PMID 25472766.
• "Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin. ". Blood. 2017. PMID 28559357.
• "Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy. ". Oncotarget. 2016. PMID 26840092.
• "Factors associated with the platelet count in patients with chronic hepatitis C.". Thromb Res. 2015. PMID 25728497.