THOC1

THOC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WXP
Dynodwyr
Cyfenwau	THOC1, HPR1, P84, P84N5, THO complex 1
Dynodwyr allanol	OMIM: 606930 HomoloGene: 38012 GeneCards: THOC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001948, GO:0016582 protein binding • RNA binding Cydrannau o'r gell • cytoplasm • transcription export complex • nuclear matrix • intercellular bridge • THO complex • THO complex part of transcription export complex • cnewyllyn cell • nucleoplasm • cytosol • nuclear speck Prosesau biolegol • regulation of DNA recombination • mRNA transport • GO:0033168, GO:0036404, GO:1902360 RNA processing • GO:0009373 regulation of transcription, DNA-templated • negative regulation of DNA damage checkpoint • mRNA processing • regulation of DNA-templated transcription, elongation • viral mRNA export from host cell nucleus • transcription, DNA-templated • positive regulation of DNA-templated transcription, elongation • negative regulation of isotype switching to IgA isotypes • RNA splicing • replication fork processing • GO:0072468 signal transduction • GO:0097285 apoptotic process • RNA export from nucleus • mRNA export from nucleus • mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9984	n/a
Ensembl	ENSG00000079134	n/a
UniProt	Q96FV9	n/a
RefSeq (mRNA)	NM_005131	n/a
RefSeq (protein)	NP_005122	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn THOC1 yw THOC1 a elwir hefyd yn THO complex 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18p11.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THOC1.

• P84
• HPR1
• P84N5

Llyfryddiaeth

• "Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. ". Ann Clin Lab Sci. 2008. PMID 18469354.
• "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. ". Cancer Res. 2007. PMID 17699767.
• "Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer. ". Biochem Biophys Res Commun. 2015. PMID 26545775.
• "Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells. ". Mol Med Rep. 2014. PMID 24682263.
• "Transcriptional regulation of hTREX84 in human cancer cells.". PLoS One. 2012. PMID 22952718.