THBD

THBD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
Dynodwyr
Cyfenwau	THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
Dynodwyr allanol	OMIM: 188040 HomoloGene: 308 GeneCards: THBD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • signaling receptor activity Cydrannau o'r gell • integral component of membrane • cell surface • Cellbilen • integral component of plasma membrane • bilen • apicolateral plasma membrane • vacuolar membrane • extracellular space Prosesau biolegol • hemostasis • female pregnancy • negative regulation of platelet activation • response to lipopolysaccharide • response to cAMP • negative regulation of fibrinolysis • blood coagulation • response to X-ray • GO:0072468 signal transduction • negative regulation of blood coagulation • leukocyte migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7056	n/a
Ensembl	ENSG00000178726	n/a
UniProt	P07204	n/a
RefSeq (mRNA)	NM_000361	n/a
RefSeq (protein)	NP_000352	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn THBD yw THBD a elwir hefyd yn Thrombomodulin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THBD.

• TM
• THRM
• AHUS6
• BDCA3
• CD141
• THPH12

Llyfryddiaeth

• "Association of thrombomodulin c.1418C>T polymorphism and venous thromboembolism. ". Gene. 2017. PMID 28710034.
• "Juvenile myelomonocytic leukemia with prominent CD141+ myeloid dendritic cell differentiation. ". Hum Pathol. 2017. PMID 28414089.
• "Identification of Genetic Aberrations in Thrombomodulin Gene in Patients With Recurrent Venous Thromboembolism. ". Clin Appl Thromb Hemost. 2017. PMID 28049360.
• "Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT). ". PLoS One. 2016. PMID 27512995.
• "Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model.". Radiat Res. 2016. PMID 27459702.