TH

TH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2XSN, 4J6S
Dynodwyr
Cyfenwau	TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase
Dynodwyr allanol	OMIM: 191290 HomoloGene: 307 GeneCards: TH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • tetrahydrobiopterin binding • tyrosine 3-monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen • ferrous iron binding • oxygen binding • metal ion binding • dopamine binding • enzyme binding • oxidoreductase activity • iron ion binding • ferric iron binding • GO:0001948, GO:0016582 protein binding • amino acid binding • monooxygenase activity • protein domain specific binding Cydrannau o'r gell • cytoplasm • cytosol • mitocondria • neuron projection • cytoplasmic side of plasma membrane • cnewyllyn cell • synaptic vesicle • melanosome membrane • terminal bouton • perikaryon • axon • neuronal cell body • smooth endoplasmic reticulum • dendrite • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle Prosesau biolegol • regulation of heart contraction • response to salt stress • response to steroid hormone • response to amphetamine • isoquinoline alkaloid metabolic process • response to zinc ion • terpene metabolic process • learning • epinephrine biosynthetic process • synaptic transmission, dopaminergic • circadian sleep/wake cycle • multicellular organism aging • animal organ morphogenesis • response to growth factor • response to ethanol • cellular response to glucose stimulus • phthalate metabolic process • locomotory behavior • response to light stimulus • anatomical structure morphogenesis • response to nicotine • response to metal ion • Cof • heart development • response to nutrient levels • embryonic camera-type eye morphogenesis • social behavior • cellular response to manganese ion • response to ether • sphingolipid metabolic process • response to immobilization stress • norepinephrine biosynthetic process • gwybyddiaeth • dopamine biosynthetic process • response to corticosterone • cellular response to nicotine • cellular response to alkaloid • mating behavior • response to electrical stimulus • response to isolation stress • glycoside metabolic process • aromatic amino acid family metabolic process • response to lipopolysaccharide • cerebral cortex development • response to pyrethroid • pigmentation • phytoalexin metabolic process • response to herbicide • golwg • response to estradiol • response to hypoxia • GO:1904578 response to organic cyclic compound • eating behavior • cellular response to growth factor stimulus • heart morphogenesis • response to water deprivation • catecholamine biosynthetic process • neurotransmitter biosynthetic process • response to peptide hormone • sensory perception of sound • response to activity • fatty acid metabolic process • eye photoreceptor cell development • response to insecticide • dopamine biosynthetic process from tyrosine • aminergic neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7054	n/a
Ensembl	ENSG00000180176	n/a
UniProt	P07101 P78428	n/a
RefSeq (mRNA)	NM_000360 NM_199292 NM_199293	n/a
RefSeq (protein)	NP_000351 NP_954986 NP_954987 NP_954986.2 NP_954987.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TH yw TH a elwir hefyd yn Tyrosine hydroxylase a Tyrosine 3-monooxygenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TH.

• TYH
• DYT14
• DYT5b

Llyfryddiaeth

• "A new knock-in mouse model of l-DOPA-responsive dystonia. ". Brain. 2015. PMID 26220941.
• "The hTH-GFP reporter rat model for the study of Parkinson's disease. ". PLoS One. 2014. PMID 25462571.
• "The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease. ". Parkinsonism Relat Disord. 2016. PMID 26732803.
• "The Effect of Perinatal Hypoxic/Ischemic Injury on Tyrosine Hydroxylase Expression in the Locus Coeruleus of the Human Neonate. ". Dev Neurosci. 2016. PMID 26647061.
• "Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.". Brain. 2015. PMID 26276013.