TGFB2

TGFB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1TFG, 2TGI, 4KXZ
Dynodwyr
Cyfenwau	TGFB2, TGF-beta2, transforming growth factor beta 2, G-TSF
Dynodwyr allanol	OMIM: 190220 HomoloGene: 2432 GeneCards: TGFB2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• type II transforming growth factor beta receptor binding; • signaling receptor binding; • type III transforming growth factor beta receptor binding; • cytokine activity; • transforming growth factor beta receptor binding; • growth factor activity; • protein homodimerization activity; • amyloid-beta binding; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity;
Cydrannau o'r gell	• extracellular region; • GO:0005578 extracellular matrix; • platelet alpha granule lumen; • extracellular space; • axon; • neuronal cell body; • collagen-containing extracellular matrix;
Prosesau biolegol	• eye development; • regulation of transforming growth factor beta2 production; • response to progesterone; • marwolaeth celloedd; • cardioblast differentiation; • positive regulation of integrin biosynthetic process; • protein phosphorylation; • positive regulation of heart contraction; • positive regulation of neuron apoptotic process; • angiogenesis; • negative regulation of epithelial cell proliferation; • uterine wall breakdown; • negative regulation of alkaline phosphatase activity; • negative regulation of macrophage cytokine production; • positive regulation of cell adhesion mediated by integrin; • cell population proliferation; • transforming growth factor beta receptor signaling pathway; • negative regulation of cell population proliferation; • positive regulation of stress-activated MAPK cascade; • cell-cell junction organization; • extrinsic apoptotic signaling pathway; • collagen fibril organization; • positive regulation of epithelial cell migration; • neutrophil chemotaxis; • positive regulation of cell growth; • response to wounding; • negative regulation of cell growth; • positive regulation of cardioblast differentiation; • glial cell migration; • wound healing; • positive regulation of ossification; • cardiac muscle cell proliferation; • positive regulation of epithelial to mesenchymal transition; • odontogenesis; • positive regulation of timing of catagen; • positive regulation of immune response; • regulation of complement-dependent cytotoxicity; • positive regulation of protein secretion; • epithelial to mesenchymal transition; • embryonic digestive tract development; • response to hypoxia; • cell-cell signaling; • positive regulation of pathway-restricted SMAD protein phosphorylation; • heart morphogenesis; • platelet degranulation; • salivary gland morphogenesis; • generation of neurons; • negative regulation of immune response; • GO:0000767 cell morphogenesis; • positive regulation of cell population proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • cell migration; • activation of protein kinase activity; • positive regulation of cell division; • cardiac epithelial to mesenchymal transition; • BMP signaling pathway; • cell development; • skeletal system development; • kidney development; • neural tube closure; • hair follicle development; • outflow tract septum morphogenesis; • membranous septum morphogenesis; • heart valve morphogenesis; • atrioventricular valve morphogenesis; • pulmonary valve morphogenesis; • endocardial cushion morphogenesis; • cardiac right ventricle morphogenesis; • ventricular trabecula myocardium morphogenesis; • endocardial cushion fusion; • atrial septum primum morphogenesis; • neural retina development; • heart development; • male gonad development; • hemopoiesis; • embryonic limb morphogenesis; • hair follicle morphogenesis; • ascending aorta morphogenesis; • dopamine biosynthetic process; • positive regulation of cell cycle; • negative regulation of Ras protein signal transduction; • somatic stem cell division; • neuron development; • inner ear development; • uterus development; • pathway-restricted SMAD protein phosphorylation; • ventricular septum morphogenesis; • atrial septum morphogenesis; • pharyngeal arch artery morphogenesis; • regulation of apoptotic process involved in outflow tract morphogenesis; • substantia propria of cornea development; • cranial skeletal system development; • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; • regulation of signaling receptor activity; • negative regulation of gene expression; • negative regulation of angiogenesis; • positive regulation of Notch signaling pathway; • SMAD protein signal transduction; • positive regulation of pri-miRNA transcription by RNA polymerase II; • embryo development ending in birth or egg hatching; • regulation of timing of catagen; • secondary palate development; • regulation of cell population proliferation; • regulation of apoptotic process; • regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologau
	7042
	n/a
	ENSG00000092969
	n/a
	P61812
	n/a
	NM_003238; NM_001135599
	n/a
	NP_001129071; NP_003229
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TGFB2 yw TGFB2 a elwir hefyd yn Transforming growth factor beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q41.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGFB2.

LDS4
G-TSF
TGF-beta2

Llyfryddiaeth

"Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs. ". Cell Cycle. 2017. PMID 27880067.
"Genetic variance of transforming growth factor β2 gene in conotruncal heart defects. ". Biomarkers. 2017. PMID 27564654.
"Phenotypic variability and diffuse arterial lesions in a family with Loeys-Dietz syndrome type 4. ". Clin Genet. 2017. PMID 27440102.
"AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis. ". Aging Cell. 2016. PMID 26853893.
"Rho GTPase signaling promotes constitutive expression and release of TGF-β2 by human trabecular meshwork cells.". Exp Eye Res. 2016. PMID 26743044.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TGFB2 - Cronfa NCBI

[1]

[2]