TGFB1 Dynodwyr Cyfenwau TGFB1 Dynodwyr allanol OMIM: 190180 HomoloGene: 540 GeneCards: TGFB1 Ontoleg y genyn Gweithrediad moleciwlaidd • type II transforming growth factor beta receptor binding • protein N-terminus binding • cytokine activity • enzyme binding • growth factor activity • GO:0003823, GO:0051635 antigen binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • protein serine/threonine kinase activator activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • type III transforming growth factor beta receptor binding • transforming growth factor beta receptor binding • identical protein binding Cydrannau o'r gell • cytoplasm • extracellular region • cnewyllyn cell • microvillus • cell surface • blood microparticle • Cellbilen • secretory granule • axon • neuronal cell body • Golgi lumen • platelet alpha granule lumen • GO:0005578 extracellular matrix • extracellular space Prosesau biolegol • positive regulation of histone deacetylation • positive regulation of transcription regulatory region DNA binding • ureteric bud development • tolerance induction to self antigen • positive regulation of protein phosphorylation • endoderm development • response to cholesterol • positive regulation of MAP kinase activity • regulation of sodium ion transport • response to progesterone • negative regulation of cell cycle • response to organic substance • mammary gland development • T cell homeostasis • negative regulation of ossification • negative regulation of hyaluronan biosynthetic process • protein phosphorylation • T cell differentiation • positive regulation of vascular permeability • animal organ regeneration • positive regulation of blood vessel endothelial cell migration • negative regulation of epithelial cell proliferation • regulation of binding • inner ear development • myelination • negative regulation of macrophage cytokine production • cell population proliferation • transforming growth factor beta receptor signaling pathway • face morphogenesis • negative regulation of cell population proliferation • positive regulation of receptor clustering • regulation of apoptotic process • positive regulation of collagen biosynthetic process • cellular response to transforming growth factor beta stimulus • pathway-restricted SMAD protein phosphorylation • regulation of DNA binding • regulation of actin cytoskeleton reorganization • negative regulation of fat cell differentiation • GO:0051247, GO:0051200 positive regulation of protein metabolic process • cell-cell junction organization • negative regulation of myoblast differentiation • positive regulation of protein kinase B signaling • common-partner SMAD protein phosphorylation • positive regulation of branching involved in ureteric bud morphogenesis • SMAD protein signal transduction • epidermal growth factor receptor signaling pathway • macrophage derived foam cell differentiation • negative regulation of blood vessel endothelial cell migration • positive regulation of protein dephosphorylation • extrinsic apoptotic signaling pathway • negative regulation of extracellular matrix disassembly • mitotic cell cycle checkpoint signaling • positive regulation of fibroblast proliferation • negative regulation of cell differentiation • regulation of branching involved in mammary gland duct morphogenesis • positive regulation of exit from mitosis • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • morphogenesis of a branching structure • regulation of SMAD protein signal transduction • positive regulation of peptidyl-serine phosphorylation • cell activation • negative regulation of neuroblast proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cell growth • negative regulation of T cell proliferation • response to wounding • negative regulation of cell growth • positive regulation of chemotaxis • protein export from nucleus • regulation of protein import into nucleus • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein import into nucleus • positive regulation of cardiac muscle cell differentiation • oligodendrocyte development • positive regulation of interleukin-17 production • inflammatory response • negative regulation of interleukin-17 production • lymph node development • T cell activation • Notch signaling pathway • GO:0033128 negative regulation of protein phosphorylation • regulation of blood vessel remodeling • SMAD protein complex assembly • regulation of striated muscle tissue development • response to vitamin D • chondrocyte differentiation • regulatory T cell differentiation • regulation of cartilage development • branch elongation involved in mammary gland duct branching • positive regulation of bone mineralization • positive regulation of epithelial cell proliferation • female pregnancy • GO:1904579 cellular response to organic cyclic compound • positive regulation of extracellular matrix assembly • cellular calcium ion homeostasis • wound healing • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • positive regulation of epithelial to mesenchymal transition • cellular response to dexamethasone stimulus • negative regulation of production of miRNAs involved in gene silencing by miRNA • GO:0019049, GO:0030683 mitigation of host defenses by virus • lens fiber cell differentiation • positive regulation of NF-kappaB transcription factor activity • extracellular matrix assembly • ATP biosynthetic process • hematopoietic progenitor cell differentiation • regulation of interleukin-23 production • positive regulation of protein secretion • frontal suture morphogenesis • epithelial to mesenchymal transition • phosphate-containing compound metabolic process • regulation of gene expression • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • negative regulation of release of sequestered calcium ion into cytosol • response to radiation • mononuclear cell proliferation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of T cell activation • positive regulation of odontogenesis • lipopolysaccharide-mediated signaling pathway • positive regulation of protein localization to nucleus • response to estradiol • regulation of cell migration • response to hypoxia • hyaluronan catabolic process • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • positive regulation of protein-containing complex assembly • protein kinase B signaling • negative regulation of cell-cell adhesion • GO:1905617 negative regulation of gene silencing by miRNA • positive regulation of regulatory T cell differentiation • cellular response to growth factor stimulus • positive regulation of pathway-restricted SMAD protein phosphorylation • mammary gland branching involved in thelarche • response to laminar fluid shear stress • GO:0010260 heneiddio • regulation of regulatory T cell differentiation • platelet degranulation • negative regulation of DNA replication • myeloid dendritic cell differentiation • salivary gland morphogenesis • receptor catabolic process • MAPK cascade • positive regulation of histone acetylation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase activity • negative regulation of protein localization to plasma membrane • positive regulation of NAD+ ADP-ribosyltransferase activity • negative regulation of immune response • regulation of cell population proliferation • negative regulation of skeletal muscle tissue development • positive regulation of peptidyl-threonine phosphorylation • positive regulation of smooth muscle cell differentiation • positive regulation of isotype switching to IgA isotypes • connective tissue replacement involved in inflammatory response wound healing • ossification involved in bone remodeling • positive regulation of apoptotic process • positive regulation of vascular endothelial growth factor production • positive regulation of superoxide anion generation • digestive tract development • cell migration • positive regulation of fibroblast migration • positive regulation of cell division • germ cell migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of mitotic cell cycle • positive regulation of SMAD protein signal transduction • positive regulation of pri-miRNA transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • liver regeneration • regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of mononuclear cell migration • cellular response to insulin-like growth factor stimulus • positive regulation of cell migration • response to immobilization stress • cellular response to mechanical stimulus • cellular response to ionizing radiation • vasculogenesis • neural tube closure • heart valve morphogenesis • heart development • neural tube development • membrane protein intracellular domain proteolysis • leukocyte migration • ventricular cardiac muscle tissue morphogenesis • positive regulation of ERK1 and ERK2 cascade • transforming growth factor beta receptor signaling pathway involved in heart development • embryonic liver development • BMP signaling pathway • cell development • GO:0097285 apoptotic process • regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of production of miRNAs involved in gene silencing by miRNA • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn TGFB1 yw TGFB1 a elwir hefyd yn Transforming growth factor beta 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGFB1.
CED
LAP
DPD1
TGFB
TGFbeta
"TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer. ". Cancer Lett . 2018. PMID 29079415 . "The c.29T>C polymorphism of the transforming growth factor beta-1 (TGFB1) gene, bone mineral density and the occurrence of low-energy fractures in patients with inflammatory bowel disease. ". Mol Biol Rep . 2017. PMID 28993955 . "Loss of regulatory characteristics in CD4+ CD25+/hi T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ". APMIS . 2017. PMID 28913840 . "TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures. ". PLoS One . 2017. PMID 28873435 . "Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate. ". Int J Pediatr Otorhinolaryngol . 2017. PMID 28802359 . 
