TFRC

TFRC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Dynodwyr
Cyfenwau	TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90, IMD46, transferrin receptor
Dynodwyr allanol	OMIM: 190010 HomoloGene: 2429 GeneCards: TFRC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • virus receptor activity • transferrin receptor activity • identical protein binding • double-stranded RNA binding • RNA binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular vesicle • integral component of membrane • recycling endosome • HFE-transferrin receptor complex • endosome • blood microparticle • bilen • melanosome • Cellbilen • integral component of plasma membrane • extracellular region • cell surface • basolateral plasma membrane • perinuclear region of cytoplasm • clathrin-coated pit • extracellular exosome • external side of plasma membrane • extracellular space • clathrin-coated vesicle membrane • GO:0016023 cytoplasmic vesicle • endosome membrane • early endosome Prosesau biolegol • endocytosis • osteoclast differentiation • positive regulation of bone resorption • receptor-mediated endocytosis • regulation of cell population proliferation • regulation of cell growth • viral entry into host cell • GO:0022415 viral process • cellular iron ion homeostasis • positive regulation of isotype switching • receptor internalization • transferrin transport • positive regulation of B cell proliferation • positive regulation of T cell proliferation • membrane organization • cellular response to leukemia inhibitory factor • iron ion transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7037	n/a
Ensembl	ENSG00000072274	n/a
UniProt	P02786	n/a
RefSeq (mRNA)	NM_001313965 NM_001313966 NM_001128148 NM_003234	n/a
RefSeq (protein)	NP_001121620 NP_001300894 NP_001300895 NP_003225	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TFRC yw TFRC a elwir hefyd yn Transferrin receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q29.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TFRC.

• T9
• TR
• TFR
• p90
• CD71
• TFR1
• TRFR
• IMD46

Llyfryddiaeth

• "The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients. ". Adv Clin Exp Med. 2016. PMID 27629729.
• "Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation. ". Biochem Biophys Res Commun. 2016. PMID 26869514.
• "Soluble form of transferrin receptor-1 level is associated with the age at first diagnosis and the risk of therapeutic intervention and iron overloading in patients with non-transfusion-dependent thalassemia. ". Ann Hematol. 2017. PMID 28707012.
• "Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool. ". Tumour Biol. 2017. PMID 28671021.
• "Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma.". Biochem Biophys Res Commun. 2017. PMID 28189691.