TFPI

TFPI
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Dynodwyr
Cyfenwau	TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
Dynodwyr allanol	OMIM: 152310 HomoloGene: 4579 GeneCards: TFPI
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • organelle membrane • extracellular region • cell surface • anchored component of membrane • Cellbilen • Reticwlwm endoplasmig • bilen • intracellular membrane-bounded organelle • extracellular space • caveola Prosesau biolegol • hemostasis • blood coagulation, extrinsic pathway • negative regulation of peptidase activity • blood coagulation • response to lipopolysaccharide • response to estradiol • cellular response to lipopolysaccharide • negative regulation of endopeptidase activity • cellular response to interleukin-1 • negative regulation of blood coagulation • cellular response to steroid hormone stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7035	n/a
Ensembl	ENSG00000003436	n/a
UniProt	P10646	n/a
RefSeq (mRNA)	NM_001032281 NM_006287 NM_001318941 NM_001329239 NM_001329240 NM_001329241	n/a
RefSeq (protein)	NP_001027452 NP_001305870 NP_001316168 NP_001316169 NP_001316170 NP_006278	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TFPI yw TFPI a elwir hefyd yn Tissue factor pathway inhibitor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TFPI.

• EPI
• TFI
• LACI
• TFPI1

Llyfryddiaeth

• "Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels. ". Genet Epidemiol. 2017. PMID 28421636.
• "Tissue factor pathway inhibitor for prediction of placenta-mediated adverse pregnancy outcomes in high-risk women: AngioPred study. ". PLoS One. 2017. PMID 28328938.
• "Tissue Factor Pathway Inhibitor-1 Is a Valuable Marker for the Prediction of Deep Venous Thrombosis and Tumor Metastasis in Patients with Lung Cancer. ". Biomed Res Int. 2017. PMID 28246607.
• "Targeting TFPI for hemophilia treatment. ". Thromb Res. 2016. PMID 27207418.
• "Oestrogens Downregulate Tissue Factor Pathway Inhibitor through Oestrogen Response Elements in the 5'-Flanking Region.". PLoS One. 2016. PMID 26999742.