TEAD4

TEAD4
Dynodwyr
Cyfenwau	TEAD4, EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, TEA domain transcription factor 4
Dynodwyr allanol	OMIM: 601714 HomoloGene: 74463 GeneCards: TEAD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • transcription regulator complex • cnewyllyn cell Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • skeletal system development • muscle organ development • transcription initiation from RNA polymerase II promoter • GO:0009373 regulation of transcription, DNA-templated • hippo signaling • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • embryonic organ development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7004	n/a
Ensembl	ENSG00000197905	n/a
UniProt	Q15561	n/a
RefSeq (mRNA)	NM_201443 NM_003213 NM_201441	n/a
RefSeq (protein)	NP_003204 NP_958849 NP_958851	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TEAD4 yw TEAD4 a elwir hefyd yn TEA domain transcription factor 4 a Transcriptional enhancer factor TEF-3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TEAD4.

• TEF3
• RTEF1
• TEF-3
• EFTR-2
• TEFR-1
• TCF13L1
• hRTEF-1B

Llyfryddiaeth

• "Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. ". Oncogene. 2016. PMID 26387538.
• "RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. ". Exp Biol Med (Maywood). 2015. PMID 26041389.
• "DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. ". Oncogene. 2017. PMID 28368398.
• "Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. ". Pediatr Blood Cancer. 2017. PMID 27966820.
• "Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer.". Oncotarget. 2016. PMID 26885617.